Effects of ionizing radiation on the heart.
Effects of ionizing radiation on the heart.
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DOI：
10.1016/j.mrrev.2016.07.003
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发表时间：
2016-10
期刊：
影响因子：
--
通讯作者：
Hauer-Jensen M
中科院分区：
文献类型：
--
作者：
Boerma M;Sridharan V;Mao XW;Nelson GA;Cheema AK;Koturbash I;Singh SP;Tackett AJ;Hauer-Jensen M
本文概述了电离辐射对心脏影响的研究。临床研究已经确定了辐射诱发的心脏病的早期和晚期表现，这是当心脏的全部或部分位于辐射场中时对胸部肿瘤进行放射治疗的副作用。对临床前动物模型的研究有助于我们了解辐射可能损伤心脏的机制。最近对人类受试者的观察表明，电离辐射在比以前认为的剂量更低的剂量下可能会对心血管产生影响。这导致在动物模型中检查低剂量光子和低剂量带电粒子照射。最后，研究已经开始确定用于检测心脏辐射损伤的非侵入性方法和可以预防或减轻这些不良影响的干预措施。总之，这项正在进行的研究应该增加我们对心血管辐射损伤的生物学机制的了解，确定早期检测的非侵入性生物标志物，以及可能预防或减轻这些不良反应的潜在干预措施。
This article provides an overview of studies addressing effects of ionizing radiation on the heart. Clinical studies have identified early and late manifestations of radiation-induced heart disease, a side effect of radiation therapy to tumors in the chest when all or part of the heart is situated in the radiation field. Studies in preclinical animal models have contributed to our understanding of the mechanisms by which radiation may injure the heart. More recent observations in human subjects suggest that ionizing radiation may have cardiovascular effects at lower doses than was previously thought. This has led to examinations of low-dose photons and low-dose charged particle irradiation in animal models. Lastly, studies have started to identify noninvasive methods for detection of cardiac radiation injury and interventions that may prevent or mitigate these adverse effects. Altogether, this ongoing research should increase our knowledge of biological mechanisms of cardiovascular radiation injury, identify non-invasive biomarkers for early detection, and potential interventions that may prevent or mitigate these adverse effects.
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影响因子：
158.5
作者：
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