Effect of estrogen and angiotensin-converting enzyme inhibitor on vascular remodeling in ovariectomized spontaneously hypertensive rats
Effect of estrogen and angiotensin-converting enzyme inhibitor on vascular remodeling in ovariectomized spontaneously hypertensive rats
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DOI：
10.1097/01.gme.0000222472.08593.e4
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发表时间：
2006-05-01
影响因子：
2.7
通讯作者：
Hernandez, Isabel
中科院分区：
文献类型：
--
作者：
Garcia, Maria P.;Gimenez, Jose;Hernandez, Isabel
目的：本研究评估雌激素是否影响血管紧张素转换酶抑制剂在预防高血压诱导的血管重构中的作用，并研究了该作用中涉及的信号机制。设计：将10周龄雌性自发性高血压大鼠切除卵巢（OVX），并随机分为以下组：未处理的OVX和用17 β-雌二醇（雌二醇，1.5mg）和/或卡托普利（5 mg/kg/天）处理。测定收缩压的变化，直至18周。当时，心脏和肠系膜被切除。冠状动脉血管的结构变化通过图像分析仪进行定量。结果：Escherichia coli能增强卡托普利对OVX大鼠的降压作用。与卡托普利治疗略有修改中横截面积和壁腔心肌小动脉OVX自发性高血压大鼠，而共同管理的卡托普利和雌二醇显着降低中横截面积，壁腔比，血管周围纤维化OVX自发性高血压大鼠。单用卡托普利并没有显着抑制细胞外信号调节激酶1/2磷酸化，而共同管理的卡托普利和雌二醇显着衰减此parameter.Conclusions：这些结果表明，雌激素可能会提高血管紧张素转换酶抑制介导的改善高血压血管重塑，这可能是部分介导的通过抑制细胞外信号调节激酶1/2。
Objective: The present study evaluated whether estrogen influences the effect of angiotensin-converting enzyme inhibition in preventing the vascular remodeling induced by hypertension and also investigated the signal mechanism involved in that effect.Design: Ten-week-old female spontaneously hypertensive rats were ovariectomized (OVX) and randomly assigned to the groups: untreated OVX and treated with 17 beta-estradiol (estradiol, 1.5 mg) and/or captopril (5 mg/kg/day). Evolution of systolic blood pressure was determined until 18 weeks. At that time, the heart and mesentery were excised. Structural changes in coronary vessels were quantified by an image analyzer. Inmunoblotting was performed on mesenteric arteries for determination of phosphorylated (ERK1/2).Results: Estradiol treatment enhanced the antihypertensive effect of captopril in OVX rats. Treatment with captopril slightly modified the media cross-sectional area and wall-to-lumen of myocardial arterioles from OVX spontaneously hypertensive rats, whereas coadministration of captopril and estradiol significantly reduced the media cross-sectional area, wall-to-lumen ratio, and perivascular fibrosis in OVX spontaneously hypertensive rats. Captopril alone did not significantly inhibit extracellular signal-regulated kinase 1/2 phosphorylation, whereas coadministration of captopril and estradiol significantly attenuated this parameter.Conclusions: These results indicate that estrogen may enhance the angiotensin-converting enzyme inhibition-mediated improvement of vascular remodeling in hypertension, which may be partly mediated via inhibition of extracellular signal-regulated kinase 1/2.