Stress, Meditation, and Alzheimer's Disease Prevention: Where The Evidence Stands.
Stress, Meditation, and Alzheimer's Disease Prevention: Where The Evidence Stands.
复制标题
DOI：
10.3233/jad-142766
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Khalsa DS
中科院分区：
文献类型：
--
作者：
Khalsa DS
虽然冥想被认为有5000多年的历史，但对它的科学研究还处于起步阶段。减轻应激的广泛负面生化效应是阿尔茨海默病（AD）预防的一个表面讨论的目标，但可能是至关重要的。本文综述了生活方式和压力作为阿尔茨海默病的可能因素，以及冥想对认知和幸福感的影响，以减少神经变性和预防阿尔茨海默病。这篇综述强调了Kirtan Kriya (KK)，这是一种简单、经济有效的冥想技术，每天只需要12分钟，它已经成功地用于改善主观认知能力下降、轻度认知障碍和高度紧张的照顾者的记忆，这些人随后发展为AD的风险都增加了。KK还被证明可以改善睡眠，减少抑郁，减少焦虑，下调炎症基因，上调免疫系统基因，改善胰岛素和葡萄糖调节基因，并使端粒酶增加43%；有史以来最大的一次。KK还可以改善心理-精神健康或精神健康，对维持认知功能和预防AD很重要。KK对于上了年纪的人来说很容易学习和练习。这篇综述的前提是，总的来说，冥想，特别是KK，以及其他方式，如饮食调整，体育锻炼，精神刺激和社交，可能是AD预防计划的一部分。
Although meditation is believed to be over five thousand years old, scientific research on it is in its infancy. Mitigating the extensive negative biochemical effects of stress is a superficially discussed target of Alzheimer’s disease (AD) prevention, yet may be critically important. This paper reviews lifestyle and stress as possible factors contributing to AD and meditation’s effects on cognition and well-being for reduction of neurodegeneration and prevention of AD. This review highlights Kirtan Kriya (KK), an easy, cost effective meditation technique requiring only 12 minutes a day, which has been successfully employed to improve memory in studies of people with subjective cognitive decline, mild cognitive impairment, and highly stressed caregivers, all of whom are at increased risk for subsequent development of AD. KK has also been shown to improve sleep, decrease depression, reduce anxiety, down regulate inflammatory genes, upregulate immune system genes, improve insulin and glucose regulatory genes, and increase telomerase by 43%; the largest ever recorded. KK also improves psycho-spiritual well-being or spiritual fitness, important for maintenance of cognitive function and prevention of AD. KK is easy to learn and practice by aging individuals. It is the premise of this review that meditation in general, and KK specifically, along with other modalities such as dietary modification, physical exercise, mental stimulation, and socialization, may be beneficial as part of an AD prevention program.