ROLE AND REGULATION OF RUNX2 IN OSTEOGENESIS
ROLE AND REGULATION OF RUNX2 IN OSTEOGENESIS
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DOI：
10.22203/ecm.v028a19
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发表时间：
2014-07-01
影响因子：
3.1
通讯作者：
Stoddart, M. J.
中科院分区：
文献类型：
--
作者：
Bruderer, M.;Richards, R. G.;Stoddart, M. J.
runt相关转录因子2 （RUNX2）是一种与成骨细胞表型密切相关的转录因子。虽然经常被提及，但其调控的复杂性及其在成骨细胞分化途径中的相互作用往往被忽视。本综述旨在总结其在转录，翻译和翻译后水平的调控知识。此外，我们还将讨论成骨研究中常用的因子对RUNX2的调控。
Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its interactions within the osteoblast differentiation pathway are often overlooked. This review aims to summarise the knowledge of its regulation at the transcriptional, translational and post-translational level. In addition, the regulation of RUNX2 by factors commonly used during osteogenic studies will be discussed.