Lost to follow-up among pregnant women in a multi-site community based maternal and newborn health registry: a prospective study.
Lost to follow-up among pregnant women in a multi-site community based maternal and newborn health registry: a prospective study.
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DOI：
10.1186/1742-4755-12-s2-s4
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发表时间：
2015
影响因子：
3.4
通讯作者：
Esamai F
中科院分区：
文献类型：
--
作者：
Marete I;Tenge C;Chemweno C;Bucher S;Pasha O;Ramadurg UY;Mastiholi SC;Chiwila M;Patel A;Althabe F;Garces A;Moore JL;Liechty EA;Derman RJ;Hibberd PL;Hambidge K;Goldenberg RL;Carlo WA;Koso-Thomas M;McClure EM;Esamai F
在进行流行病学研究时，密切监测失访（LTFU）率非常重要。高LTFU率可能导致研究结果不完整，进而可能导致试验或研究偏倚，威胁结果的有效性。在基于社区的前瞻性围产期流行病学研究中，关于LTFU的信息很少。本文报告了一项大型社区妊娠登记研究中LTFU的发生率，描述了LTFU母亲的社会人口学特征和妊娠/分娩结局。数据来自全球妇幼健康研究网络孕产妇新生儿健康登记处（MNHR）的一项前瞻性、基于人群的观察性研究。这是一项多中心、国际研究，孕妇在妊娠中期入组，随后分娩和分娩后42天入组。LTFU的风险计算在95%CI内。本研究共入组282，626例受试者，其中4，893例失访。总体而言，随访的LTFU率为1.7%。与LTFU较高相关的因素包括不知道末次月经的母亲（RR 2.2，95% CI 1.1，4.4），母亲年龄< 20岁（RR 1.2，95% CI 1.1，1.3），未受过正规教育的妇女（RR 1.2，95% CI 1.1，1.4），以及到政府诊所接受产前保健（RR 2.0，95% CI 1.4，2.8）。与LTFU率较高相关的产后因素包括新生儿存在喂养问题（RR 1.6，94%CI 1.2，2.2）。在这项基于社区的登记研究中，LTFU率较低（1.7%）。产妇年龄、产妇教育水平、入学时的妊娠状态和使用政府设施进行ANC是与LTFU相关的因素。确保社区研究中的代表性和高保留率的策略对于告知公共卫生目标的进展非常重要。在Clinicaltrials.gov注册（ID#NCT 01073475）。
It is important when conducting epidemiologic studies to closely monitor lost to follow up (LTFU) rates. A high LTFU rate may lead to incomplete study results which in turn can introduce bias to the trial or study, threatening the validity of the findings. There is scarce information on LTFU in prospective community-based perinatal epidemiological studies. This paper reports the rates of LTFU, describes socio-demographic characteristics, and pregnancy/delivery outcomes of mothers LTFU in a large community-based pregnancy registry study. Data were from a prospective, population-based observational study of the Global Network for Women's and Children's Health Research Maternal Newborn Health Registry (MNHR). This is a multi-centre, international study in which pregnant women were enrolled in mid-pregnancy, followed through parturition and 42 days post-delivery. Risk for LTFU was calculated within a 95%CI. A total of 282,626 subjects were enrolled in this study, of which 4,893 were lost to follow-up. Overall, there was a 1.7% LTFU to follow up rate. Factors associated with a higher LTFU included mothers who did not know their last menstrual period (RR 2.2, 95% CI 1.1, 4.4), maternal age of < 20 years (RR 1.2, 95% CI 1.1, 1.3), women with no formal education (RR 1.2, 95% CI 1.1, 1.4), and attending a government clinic for antenatal care (RR 2.0, 95% CI 1.4, 2.8). Post-natal factors associated with a higher LTFU rate included a newborn with feeding problems (RR 1.6, 94% CI 1.2, 2.2). The LTFU rate in this community-based registry was low (1.7%). Maternal age, maternal level of education, pregnancy status at enrollment and using a government facility for ANC are factors associated with being LTFU. Strategies to ensure representation and high retention in community studies are important to informing progress toward public health goals. Registration at the Clinicaltrials.gov (ID# NCT01073475).