Human theta oscillations exhibit task dependence during virtual maze navigation
Human theta oscillations exhibit task dependence during virtual maze navigation
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DOI：
10.1038/21645
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发表时间：
1999-06-24
期刊：
影响因子：
64.8
通讯作者：
Madsen, JR
中科院分区：
文献类型：
--
作者：
Kahana, MJ;Sekuler, R;Madsen, JR
θ振荡（频率为4-8 Hz的脑电图活动）长期以来一直与啮齿动物的空间导航有关（1-3）;然而，θ振荡器在人类空间导航中的作用尚未被探索。在这里，我们描述了从癫痫患者学习导航计算机生成的迷宫硬膜下录音。对原始颅内信号的目视检查显示，在包括颞叶皮质在内的许多皮质区域出现了显著的高振幅慢波振荡。光谱分析表明，这些振荡是在θ波段。theta活动的这些发作通常持续几个周期，取决于任务特征。θ振荡在更复杂的迷宫中发生得更频繁;它们在回忆试验中也比在学习试验中更频繁。
Theta oscillations (electroencephalographic activity with a frequency of 4-8 Hz) have long been implicated in spatial navigation in rodents(1-3); however, the role of theta oscillators in human spatial navigation has not been explored. Here we describe subdural recordings from epileptic patients learning to navigate computer-generated mazes. Visual inspection of the raw intracranial signal revealed striking episodes of high-amplitude slow-wave oscillations at a number of areas of the cortex, including temporal cortex. Spectral analysis showed that these oscillations were in the theta band. These episodes of theta activity, which typically last several cycles, are dependent on task characteristics. Theta oscillations occur more frequently in more complex mazes; they are also more frequent during recall trials than during learning trials.