Involvement of Mitochondrial Phospholipid Hydroperoxide Glutathione Peroxidase as an Antiapoptotic Factor
Involvement of Mitochondrial Phospholipid Hydroperoxide Glutathione Peroxidase as an Antiapoptotic Factor
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DOI：
10.1159/000046877
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发表时间：
2001-02
期刊：
影响因子：
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通讯作者：
K. Nomura;H. Imai;T. Koumura;Y. Nakagawa
中科院分区：
文献类型：
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作者：
K. Nomura;H. Imai;T. Koumura;Y. Nakagawa
尽管超氧化物和氢过氧化物等活性氧 (ROS) 已知可诱导细胞凋亡，但人们对线粒体 ROS 的凋亡信号传导知之甚少。最近的证据表明，线粒体中的抗氧化酶可能负责调节细胞色素 C 的释放和细胞凋亡。本文探讨了有关线粒体抗氧化酶（尤其是磷脂氢过氧化物谷胱甘肽过氧化物酶）作用的当前知识状况。还提出了通过脂质氢过氧化物释放细胞色素c的模型。
Although reactive oxygen species (ROS) such as superoxide and hydroperoxide are known to induce apoptotic cell death, little is known as to the apoptotic death signaling of mitochondrial ROS. Recent evidence has suggested that antioxidant enzymes in mitochondria may be responsible for the regulation of cytochrome c release and apoptotic cell death. This paper examines the current state of knowledge regarding the role of mitochondrial antioxidant enzymes, especially phospholipid hydroperoxide glutathione peroxidase. A model for the release of cytochrome c by lipid hydroperoxide has also been proposed.