The effect of ultraviolet light on the frequency of a genetic duplication in Salmonella typhimurium.
The effect of ultraviolet light on the frequency of a genetic duplication in Salmonella typhimurium.
复制标题
紫外线对鼠伤寒沙门氏菌基因复制频率的影响。
DOI：
10.2307/3574501
复制
发表时间：
1976
影响因子：
3.4
通讯作者：
R. Morgan
中科院分区：
文献类型：
--
作者：
G. Hoffmann;R. Morgan
在鼠伤寒沙门氏菌中发现了一种基因复制，几乎涉及三分之一的染色体。这种复制以大约10/sup -4/每个细胞的自发频率发生在选择性复制的培养基上。将细胞暴露在紫外线下后，重复发生的频率增加。紫外线引起的损伤刺激了复制的形成，受到光修复。自发和诱导的merodiploids遗传不稳定，产生单倍体的频率很高。除了诱导单倍体株的重复外，紫外线照射还加速了二倍体株重复的丧失。
A genetic duplication which involves almost one-third of the chromosome has been described in the bacterium Salmonella typhimurium. This duplication occurs at a spontaneous frequency of approximately 10/sup -4/ per cell plated on medium selective for the duplication. Following exposure of cells to ultraviolet light, the frequency of occurrence of the duplication is increased. The ultraviolet light-induced damage which stimulates duplication formation is subject to photorepair. The spontaneous and induced merodiploids are genetically unstable and produce haploids at high frequency. In addition to inducing the duplication in haploid strains, ultraviolet light exposure accelerates loss of the duplication in merodiploid strains.