Amplification of tumor inducing putative cancer stem cells (CSCs) by vitamin A/retinol from mammary tumors.
Amplification of tumor inducing putative cancer stem cells (CSCs) by vitamin A/retinol from mammary tumors.
复制标题
通过来自乳腺肿瘤的维生素 A/视黄醇扩增肿瘤诱导假定的癌症干细胞 (CSC)。
DOI：
10.1016/j.bbrc.2013.05.141
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发表时间：
2013
影响因子：
3.1
通讯作者：
Khillan,JaspalS
中科院分区：
文献类型：
--
作者：
Sharma,RohitB;Wang,Qingde;Khillan,JaspalS
Solid tumors contain a rare population of cancer stem cells (CSCs) that are responsible for relapse and metastasis. The existence of CSC however, remains highly controversial issue. Here we present the evidence for putative CSCs from mammary tumors amplified by vitamin A/retinol signaling. The cells exhibit mammary stem cell specific CD29hi/CD49fhi/CD24himarkers, resistance to radiation and chemo therapeutic agents and form highly metastatic tumors in NOD/SCID mice. The cells exhibit indefinite self renewal as cell lines. Furthermore, the cells exhibit impaired retinol metabolism and do not express enzymes that metabolize retinol into retinoic acid. Vitamin A/retinol also amplified putative CSCs from breast cancer cell lines that form highly aggressive tumors in NOD SCID mice. The studies suggest that high purity putative CSCs can be isolated from solid tumors to establish patient specific cell lines for personalized therapeutics for pre-clinical translational applications. Characterization of CSCs will allow understanding of basic cellular and molecular pathways that are deregulated, mechanisms of tumor metastasis and evasion of therapies that has direct clinical relevance.
