Metabolomic profile of arterial stiffness in aged adults
Metabolomic profile of arterial stiffness in aged adults
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DOI：
10.1177/1479164117733627
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发表时间：
2018-01-01
影响因子：
2.4
通讯作者：
Kovalik, Jean-Paul
中科院分区：
文献类型：
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作者：
Koh, Angela S.;Gao, Fei;Kovalik, Jean-Paul
背景：动脉硬化增加是老年人心血管健康下降的重要原因。全身燃料代谢的变化可能与动脉僵硬度的变化在老龄adult.Methods：有针对性的高效液相色谱和气相色谱质谱法被用来测量84循环代谢物在一组社区老年人（n=141，58%的男性，平均年龄= 70.611.2岁）没有心血管疾病。在基础模型和调整模型中，我们将测量的代谢物与颈动脉-股动脉脉搏波速度（通过压平眼压计评估）相关联。
Background: Increasing arterial stiffness is an important contributor to declining cardiovascular health in ageing. Changes in whole-body fuel metabolism could be related to alterations in arterial stiffness in ageing adults.Methods: Targeted high-performance liquid and gas chromatography mass spectrometry were used to measure 84 circulating metabolites in a group of community elderly adults (n=141, 58% men; mean age=70.611.2years) without cardiovascular disease. In basic and adjusted models, we correlated the measured metabolites to carotid-femoral pulse wave velocity assessed by applanation tonometry.Results: Age (beta=0.10, p