Problems associated with glucose toxicity: Role of hyperglycemia-induced oxidative stress
Problems associated with glucose toxicity: Role of hyperglycemia-induced oxidative stress
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DOI：
10.3748/wjg.15.4137
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发表时间：
2009-09-07
影响因子：
4.3
通讯作者：
Oshita, Shuzo
中科院分区：
文献类型：
--
作者：
Kawahito, Shinji;Kitahata, Hiroshi;Oshita, Shuzo
葡萄糖稳态缺乏导致血糖浓度慢性升高。与生理葡萄糖浓度相反，慢性超生理葡萄糖浓度对大量器官和组织产生负面影响。葡萄糖毒性是指由于慢性高血糖导致的胰岛素分泌减少和胰岛素抵抗增加。现在普遍认为，葡萄糖毒性通过影响P细胞的分泌而参与糖尿病的恶化。已经提出了几种机制来解释高血糖症的不良影响。发现持续性高血糖引起中性粒细胞功能下降。因此，感染是急性期葡萄糖毒性引起的主要问题。换句话说，持续的高血糖不仅在慢性期而且在急性期都是危及生命的危险因素，并且它成为感染的危险因素，特别是在围手术期。(C)2009 WJG出版社和百世登。All rights reserved.
Glucose homeostasis deficiency leads to a chronic increase in blood glucose concentration. In contrast to physiological glucose concentration, chronic superphysiological glucose concentration negatively affects a large number of organs and tissues. Glucose toxicity means a decrease in insulin secretion and an increase in insulin resistance due to chronic hyperglycemia. It is now generally accepted that glucose toxicity is involved in the worsening of diabetes by affecting the secretion of P-cells. Several mechanisms have been proposed to explain the adverse effects of hyperglycemia. It was found that persistent hyperglycemia caused the functional decline of neutrophils. Infection is thus the main problem resulting from glucose toxicity in the acute phase. In other words, continued hyperglycemia is a life-threatening risk factor, not only in the chronic but also the acute phase, and it becomes a risk factor for infection, particularly in the perioperative period. (C) 2009 The WJG Press and Baishideng. All rights reserved.