Recent sexual violence exposure is associated with immune biomarkers of HIV susceptibility in women.
Recent sexual violence exposure is associated with immune biomarkers of HIV susceptibility in women.
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最近的性暴力暴露与女性艾滋病毒易感性的免疫生物标志物有关。
DOI：
10.1111/aji.13432
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Zumer
中科院分区：
文献类型：
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作者：
Aldous,AnnetteM;Joy,Christopher;Daniels,Jason;Jais,Mariel;Simmens,SamuelJ;Magnus,Manya;Roberts,Afsoon;Connors,Kaleigh;Capozzi,Brendan;Mohamed,Hani;Juzumaite,Monika;Devore,Heather;Moriarty,Theresa;HatchSchultz,Catherine;Zumer
问题艾滋病毒/艾滋病和性暴力协同作用，损害妇女的健康。然而，免疫生物学机制连接性暴力和增加HIV易感性知之甚少。MethodsWe进行了一项横断面试点研究的HIV未感染的妇女，比较13名妇女暴露于强迫阴道渗透在过去的12周内（暴露）与25非暴露妇女。对血浆和宫颈阴道灌洗液（CVL）中与HIV发病机制相关的49种生物标志物进行ELISA测定。暴露和非暴露之间的差异进行了分析，线性和逻辑回归，使用倾向评分加权控制年龄，种族，社会经济地位，月经周期，和避孕utility.ResultsIn CVL，暴露妇女有显着减少趋化因子MIP-3α（p<.01），MCP-1（p< .01），和抗HIV/伤口愈合血小板反应蛋白-1（p= .03）。他们还具有显著增加的炎性细胞因子IL-1α（p< 0.01），并且更可能具有可检测的伤口愈合PDGF（p= .02）。在血浆中，暴露女性的趋化因子MIP-3α（p< .01）和IL-8（p< .01）、抗炎细胞因子TGF-β（p= .02）、抗HIV/抗菌HBD-2（p= .02）和伤口愈合MMP-1（p= 0.02）减少。他们还增加了血小板反应蛋白-1（p<0.01）和组织蛋白酶B（p= 0.01）。在应用严格的错误发现率调整方法后，CVL中IL-1α（p= 0.05）和MCP-1（p= 0.03）的差异以及血浆中MIP-3α（p= 0.03）的差异仍然显着。由于这些生物标志物与艾滋病毒发病机制相关，因此调节异常可能会增加艾滋病毒的易感性。
ProblemHIV/AIDS and sexual violence act synergistically and compromise women's health. Yet, immuno‐biological mechanisms linking sexual violence and increased HIV susceptibility are poorly understood.MethodsWe conducted a cross‐sectional pilot study of HIV‐uninfected women, comparing 13 women exposed to forced vaginal penetration within the past 12 weeks (Exposed) with 25 Non‐Exposed women. ELISA assays were conducted for 49 biomarkers associated with HIV pathogenesis in plasma and cervicovaginal lavage (CVL). Differences between Exposed and Non‐Exposed were analyzed by linear and logistic regression, using propensity score weighting to control for age, race, socioeconomic status, menstrual cycle, and contraceptive use.ResultsIn CVL, Exposed women had significantly reduced chemokines MIP‐3α (p< .01), MCP‐1 (p< .01), and anti‐HIV/wound‐healing thrombospondin‐1 (p= .03). They also had significantly increased inflammatory cytokine IL‐1α (p< 0.01) and were more likely to have detectable wound‐healing PDGF (p= .02). In plasma, Exposed women had reduced chemokines MIP‐3α (p< .01) and IL‐8 (p< .01), anti‐inflammatory cytokine TGF‐β (p= .02), anti‐HIV/antimicrobial HBD–2 (p= .02), and wound‐healing MMP‐1 (p= 0.02). They also had increased thrombospondin‐1 (p< .01) and Cathepsin B (p= .01).After applying the stringent method of false discovery rate adjustment, differences for IL‐1α (p= .05) and MCP‐1 (p= .03) in CVL and MIP‐3α (p= .03) in plasma remained significant.ConclusionsWe report systemic and mucosal immune dysregulation in women exposed to sexual violence. As these biomarkers have been associated with HIV pathogenesis, dysregulation may increase HIV susceptibility.