Simulation of the progression of intervertebral disc degeneration due to decreased nutritional supply.
Simulation of the progression of intervertebral disc degeneration due to decreased nutritional supply.
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DOI：
10.1097/brs.0000000000000560
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发表时间：
2014-11-15
期刊：
影响因子：
3
通讯作者：
Brown MD
中科院分区：
文献类型：
--
作者：
Gu W;Zhu Q;Gao X;Brown MD
模拟人类椎间盘退变的过程。本研究的目的是定量分析和模拟细胞密度的变化，营养水平，蛋白多糖含量，水含量和体积变化，在人类椎间盘退变过程中使用的数值方法。了解椎间盘（IVD）退变的病因和进展对于制定有效的治疗策略对于IVD退变相关疾病至关重要。在组织退变期间，椎间盘经历细胞活力和活性的丧失、细胞外基质组成和结构的变化以及组织水平的完整性和功能的损害，这受到椎间盘中相互耦合的生物、化学、电和机械信号的显著影响。在体内表征人类椎间盘中的这些信号是困难的。基于生物力学-电化学连续介质混合理论，建立了人体椎间盘三维有限元模型。理论框架和本构关系都是基于生物物理学的。所有的材料特性都是从实验结果中得到的。通过与实验结果的比较，模拟和验证了细胞介导的椎间盘退变过程中所造成的营养水平降低在椎间盘边界。细胞密度在30天后达到平衡状态，而蛋白多糖（PG）和水分含量达到一个新的平衡状态，在55年后的盘边界营养供应减少。除PG含量在矢状方向上的分布外，模拟结果与文献中的测量结果一致。营养供应不足对椎间盘退变有长期影响。
Simulate the progression of human disc degeneration. The objective of this study was to quantitatively analyze and simulate the changes in cell density, nutrition level, proteoglycan content, water content, and volume change during human disc degeneration using a numerical method. Understanding the etiology and progression of intervertebral disc (IVD) degeneration is crucial for developing effective treatment strategies for IVD-degeneration related diseases. During tissue degeneration, the disc undergoes losses of cell viability and activities, changes in extracellular matrix composition and structure, and compromise of the tissue-level integrity and function, which is significantly influenced by the inter-coupled biological, chemical, electrical, and mechanical signals in the disc. Characterizing these signals in human discs in vivo is difficult. A realistic 3D finite element model of the human IVD was developed based on biomechano-electrochemical continuum mixture theory. The theoretical framework and the constitutive relationships were all biophysics based. All the material properties were obtained from experimental results. The cell-mediated disc degeneration process caused by lowered nutrition levels at disc boundaries was simulated and validated by comparing with experimental results. Cell density reached equilibrium state in 30 days after reduced nutrition supply at the disc boundary, while the proteoglycan (PG) and water contents reached a new equilibrium state in 55 years. The simulated results for the distributions of PG and water contents within the disc were consistent with the results measured in the literature, except for the distribution of PG content in the sagittal direction. Poor nutrition supply has a long-term effect on disc degeneration.