Abdominal obesity and risk of ischemic stroke - The Northern Manhattan Stroke Study
Abdominal obesity and risk of ischemic stroke - The Northern Manhattan Stroke Study
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DOI：
10.1161/01.str.0000075294.98582.2f
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发表时间：
2003-07-01
期刊：
影响因子：
8.3
通讯作者：
Paik, MC
中科院分区：
文献类型：
--
作者：
Suk, SH;Sacco, RL;Paik, MC
背景和目的-肥胖被公认为冠心病和死亡的危险因素。腹型肥胖和缺血性中风之间的关系仍然不太清楚。我们的目的是评估腹部肥胖作为一个独立的危险因素缺血性中风在一个多种族community. Methods，一个以人口为基础的，事件病例对照研究进行了1993年7月至1997年6月在北方曼哈顿，纽约，纽约州。首次缺血性卒中病例（n=576）（66% ≥ 65岁; 56%女性; 17%白人; 26%黑人; 55%西班牙裔）入选，并按年龄、性别和种族-民族与无卒中社区对照组（n=1142）进行匹配。所有受试者均接受了访谈和检查，并测量了腰臀比（WHR）。结果：与第一个四分位数相比，WHR的第三和第四个四分位数具有更高的脑卒中危险性（GQ 3：OR，2.4; 95% CI，1.5 - 3.9; GQ 4：OR，3.0; 95% CI，1.8 - 4.8）调整其他风险因素和BMI。即使在校正其他危险因素和BMI后，WHR等于或大于中位数的患者发生缺血性卒中的总体OR为3.0（95%CI，2.1 - 4.2）。在男性和女性以及所有种族中，腰臀比增加与卒中风险增加相关。腰臀比的影响在年轻人中更强（异质性检验，P
Background and Purpose-Obesity is well recognized as a risk factor for coronary heart disease and mortality. The relationship between abdominal obesity and ischemic stroke remains less clear. Our aim was to evaluate abdominal obesity as an independent risk factor for ischemic stroke in a multiethnic community.Methods-A population-based, incident case-control study was conducted July 1993 through June 1997 in northern Manhattan, New York, NY. Cases (n=576) of first ischemic stroke (66% greater than or equal to65 years of age; 56% women; 17% whites; 26% blacks; 55% Hispanics) were enrolled and matched by age, sex, and race-ethnicity to stroke-free community controls (n=1142). All subjects were interviewed and examined and had measurements of waist-to-hip ratio (WHR). Odds ratios (ORs) of ischemic stroke were calculated with gender-specific quartiles (GQs) and gender-specific medians of WHR adjusted for stroke risk factors and body mass index (BMI).Results-Compared with the first quartile, the third and fourth quartiles of WHR had an increased risk of stroke (GQ3: OR, 2.4; 95% CI, 1.5 to 3.9; GQ4: OR, 3.0; 95% CI, 1.8 to 4.8) adjusted for other risk factors and BMI. Those with WHR equal to or greater than the median had an overall OR of 3.0 (95% CI, 2.1 to 4.2) for ischemic stroke even after adjustment for other risk factors and BMI. Increased WHR was associated with a greater risk of stroke in men and women and in all race-ethnic groups. The effect of WHR was stronger among younger persons (test for heterogeneity, P