Pluronic F127 thermosensitive injectable smart hydrogels for controlled drug delivery system development
Pluronic F127 thermosensitive injectable smart hydrogels for controlled drug delivery system development
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DOI：
10.1016/j.jcis.2019.12.096
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发表时间：
2020-04-01
影响因子：
9.9
通讯作者：
Gough, Tim
中科院分区：
文献类型：
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作者：
Shriky, Bana;Kelly, Adrian;Gough, Tim
了解结构-性质关系对于开发新的药物递送系统至关重要。本研究探讨了Pluronic智能水凝胶制剂的性质，以供将来用作可注射的受控药物载体。智能水凝胶有望提高患者的依从性，减少副作用，减少剂量和频率。在药学上，这些系统是有吸引力的，因为它们在体内独特的溶胶-凝胶相变、生物相容性、安全性和在体温下转化为凝胶基质之前作为溶液的可注射性。我们量化的结构变化的F127系统控制温度下流动后，经历了真实的身体注射。经验公式相结合的耦合的热和剪切的依赖性，以帮助这些系统的未来应用。通过小角度X射线和中子散射原位测量的诱导结构转变揭示了可以用于定制药物释放曲线的混合取向结构。(C)2020年，任作家。爱思唯尔公司出版
Understanding structure-property relationships is critical for the development of new drug delivery systems. This study investigates the properties of Pluronic smart hydrogel formulations for future use as injectable controlled drug carriers. The smart hydrogels promise to enhance patient compliance, decrease side effects and reduce dose and frequency. Pharmaceutically, these systems are attractive due to their unique sol-gel phase transition in the body, biocompatibility, safety and injectability as solutions before transforming into gel matrices at body temperature. We quantify the structural changes of F127 systems under controlled temperature after flow, as experienced during real bodily injection. Empirical formulae combining the coupled thermal and shear dependency are produced to aid future application of these systems. Induced structural transitions measured in-situ by small angle x-ray and neutron scattering reveal mixed oriented structures that can be exploited to tailor the drug release profile. (C) 2020 The Authors. Published by Elsevier Inc.