Dietary patterns associated with inflammatory biomarkers in a Northern German population
Dietary patterns associated with inflammatory biomarkers in a Northern German population
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DOI：
10.1007/s00394-019-02000-w
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发表时间：
2020-06-01
影响因子：
5
通讯作者：
Noethlings, Ute
中科院分区：
文献类型：
--
作者：
Barbaresko, Janett;Rienks, Johanna;Noethlings, Ute
目的本研究的目的是从北方德国的一般人群样本中得出与炎症生物标志物相关的总体和性别特异性饮食模式。方法本分析纳入了德国基尔Food Chain Plus（FoCus）队列的1158名参与者（477名男性，681名女性，平均年龄：53.1岁;平均体重指数：26.2 kg/m2）。参与者完成了半定量食物频率问卷，并提供了血液样本。以C-反应蛋白（CRP）和白细胞介素6（IL-6）作为反应变量的降秩回归用于推导饮食模式。平均随访1.7年后，在112人的子样本中获得第二份血样。使用多元回归模型来检查基线时的饮食模式与随访时的炎症生物标志物之间的关联。结果：高摄入软饮料、肉类、土豆和酱料，低摄入其他谷物（面食/米饭除外）、葡萄酒、坚果、种子、素食、植物油和鱼类的总体模式与随访时CRP（OR 2.20; 95%CI 1.12，4.35）和IL-6（OR 3.14; 95%CI 1.26，7.87）呈正相关。在男性中，饮食模式以软饮料、加工肉类为主，谷物和植物性脂肪较少。在女性中，这种模式的特点是软饮料，肉类，蔬菜和低其他谷物，葡萄酒，坚果和种子。CRP的性别特异性模式与炎症生物标志物之间的关联较弱。结论：我们发现饮食模式与慢性低度炎症的生物标志物呈正相关。
Purpose The aim of the present study was to derive overall and sex-specific dietary patterns associated with inflammatory biomarkers in a general population sample from Northern Germany. Methods The present analysis included 1158 participants (477 men, 681 women, mean age: 53.1 years; mean body mass index: 26.2 kg/m(2)) of the Food Chain Plus (FoCus) cohort in Kiel, Germany. Participants completed a semi-quantitative food frequency questionnaire and provided blood samples. Reduced rank regression with C-reactive protein (CRP) and Interleukin 6 (IL-6) as response variables was used to derive dietary patterns. After a mean follow-up of 1.7 years, a second blood sample was obtained in a subsample of 112 individuals. Multiple regression models were used to examine the association between dietary patterns at baseline and inflammatory biomarkers at follow-up. Results The overall pattern characterised by high intakes of soft drinks, meat, potatoes and sauce, and low intakes of other cereals (except pasta/rice), wine, nuts, seeds, vegetarian dishes, vegetable oil, and fish was positively associated with CRP (OR 2.20; 95% CI 1.12, 4.35) and IL-6 (OR 3.14; 95% CI 1.26, 7.87) at follow-up. In men, the dietary pattern was higher in soft drinks, processed meat and low in cereals and plant-based fats. In women, the pattern was characterised by soft drinks, meat, vegetables and low in other cereals, wine, nuts, and seeds. The association between sex-specific patterns with inflammatory biomarkers was weaker for CRP. Conclusion We identified dietary patterns positively associated with established biomarkers of chronic low-grade inflammation.