Pathophysiology of colorectal peritoneal carcinomatosis: Role of the peritoneum.
Pathophysiology of colorectal peritoneal carcinomatosis: Role of the peritoneum.
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DOI：
10.3748/wjg.v22.i34.7692
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发表时间：
2016-09-14
影响因子：
4.3
通讯作者：
Van der Speeten K
中科院分区：
文献类型：
--
作者：
Lemoine L;Sugarbaker P;Van der Speeten K
结直肠癌（CRC）是世界范围内第三大常见癌症和第四大常见癌症相关死亡原因。除了淋巴和血源性传播途径外，CRC还经常引起肿瘤细胞在腹膜腔中的跨体腔传播，最终导致腹膜癌病（PC）。PC与这些处于疾病晚期的患者的不良预后和不良生活质量相关。结合肿瘤细胞减灭术和术中腹腔热化疗的局部区域治疗PC的方法已经产生了有希望的临床结果。然而，这种新方法与显著的发病率和死亡率相关。全面了解腹膜疾病传播中涉及的分子事件对于避免不必要的毒性至关重要。PC的出现是癌细胞和宿主元素之间分子串扰的结果，涉及几个明确定义的步骤，统称为腹膜转移级联。单个或成团的肿瘤细胞从原发性肿瘤上脱落，进入腹膜腔，并变得对常规的腹膜转运敏感。它们附着于远处的腹膜，随后侵入腹膜下空间，在那里血管生成维持增殖并使进一步的转移性生长成为可能。这些分子事件不是孤立的事件，而是一个连续和相互依赖的过程。在这篇文章中，我们回顾了目前关于结直肠PC发展的分子机制的数据，特别关注腹膜和外科医生在腹膜疾病传播中的作用。
Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer-related death worldwide. Besides the lymphatic and haematogenous routes of dissemination, CRC frequently gives rise to transcoelomic spread of tumor cells in the peritoneal cavity, which ultimately leads to peritoneal carcinomatosis (PC). PC is associated with a poor prognosis and bad quality of life for these patients in their terminal stages of disease. A loco-regional treatment modality for PC combining cytoreductive surgery and hyperthermic intraperitoneal peroperative chemotherapy has resulted in promising clinical results. However, this novel approach is associated with significant morbidity and mortality. A comprehensive understanding of the molecular events involved in peritoneal disease spread is paramount in avoiding unnecessary toxicity. The emergence of PC is the result of a molecular crosstalk between cancer cells and host elements, involving several well-defined steps, together known as the peritoneal metastatic cascade. Individual or clumps of tumor cells detach from the primary tumor, gain access to the peritoneal cavity and become susceptible to the regular peritoneal transport. They attach to the distant peritoneum, subsequently invade the subperitoneal space, where angiogenesis sustains proliferation and enables further metastatic growth. These molecular events are not isolated events but rather a continuous and interdependent process. In this manuscript, we review current data regarding the molecular mechanisms underlying the development of colorectal PC, with a special focus on the peritoneum and the role of the surgeon in peritoneal disease spread.
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影响因子：
3.8
作者：
Chen H;Guan R;Lei Y;Chen J;Ge Q;Zhang X;Dou R;Chen H;Liu H;Qi X;Zhou X;Chen C
通讯作者：
Chen C
影响因子：
8.8
作者：
Catalano, V.;Loupakis, F.;Graziano, F.;Torresi, U.;Bisonni, R.;Mari, D.;Fornaro, L.;Baldelli, A. M.;Giordani, P.;Rossi, D.;Alessandroni, P.;Giustini, L.;Silva, R. R.;Falcone, A.;D'Emidio, S.;Fedeli, S. L.
通讯作者：
Fedeli, S. L.
DOI：
10.1007/s13304-011-0071-x
发表时间：
2011-06-01
期刊：
UPDATES IN SURGERY-ITALY
影响因子：
--
作者：
Altomare, Donato F.;Tedeschi, Michele;Rinaldi, Marcella
通讯作者：
Rinaldi, Marcella
影响因子：
3.1
作者：
Bae, Sung Joon;Shin, Ui Sup;Park, Sun Hoo
通讯作者：
Park, Sun Hoo
影响因子：
2.7
作者：
Brabletz, T;Hlubek, F;Kirchner, T
通讯作者：
Kirchner, T