Mechanisms of metastasis.
Mechanisms of metastasis.
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DOI：
10.1186/bcr1988
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发表时间：
2008
影响因子：
7.4
通讯作者：
Alsarraj, Jude
中科院分区：
文献类型：
--
作者：
Hunter, Kent W;Crawford, Nigel P S;Alsarraj, Jude
转移是一个极其复杂的过程，仍然是癌症治疗中的一个主要问题。事实上，癌症患者可能在原发肿瘤确诊数年甚至数十年后发生转移，这使得转移过程更加复杂。多年来，人们提出了许多假说，试图解释转移过程的低效率，但这些理论都不能完全解释目前的生物学和临床观察。在这篇综述中，我们总结了一些被提出的模型，这些模型是为了理解肿瘤的传播和定植以及转移进展的机制而建立的。
Metastasis is an enormously complex process that remains to be a major problem in the management of cancer. The fact that cancer patients might develop metastasis after years or even decades from diagnosis of the primary tumor makes the metastatic process even more complex. Over the years many hypotheses were developed to try to explain the inefficiency of the metastatic process, but none of these theories completely explains the current biological and clinical observations. In this review we summarize some of the proposed models that were developed in attempt to understand the mechanisms of tumor dissemination and colonization as well as metastatic progression.