Cellular interactions in the development of the olfactory system: an ablation and homotypic transplantation analysis.
Cellular interactions in the development of the olfactory system: an ablation and homotypic transplantation analysis.
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嗅觉系统发育中的细胞相互作用：消融和同型移植分析。
DOI：
10.1002/neu.1063
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
NorgrenJr,RB
中科院分区：
文献类型：
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作者：
Wang,X;Gao,C;NorgrenJr,RB
在当前的研究中，我们解决了两个问题：第一，嗅板对于嗅球和整个端脑的发育是必需的吗？其次，嗅板是否为嗅球提供细胞？我们通过在产生嗅觉神经之前单方面消融鸡胚胎中的嗅觉基板来解决这些问题，并且在第二系列实验中，通过用鹌鹑嗅觉基板替换被消融的小鸡嗅觉基板。我们的结果表明，嗅板对于嗅球发育至关重要，但对于端脑其余部分的发育不是必需的。此外，我们的结果支持 LHRH 神经元和嗅神经胶质细胞起源于嗅基板的假设，但不支持嗅球内其他细胞类型的嗅基板起源。 © 2001 John Wiley & Sons, Inc. J Neurobiol 49: 29–39, 2001
In the current study, we addressed two questions: First, is the olfactory placode necessary for the development of the olfactory bulb and the entire telencephalon? Second, does the olfactory placode contribute cells to the olfactory bulb? We addressed these questions by unilaterally ablating the olfactory placode in chick embryos before an olfactory nerve was produced and, in a second series of experiments, by replacing the ablated chick olfactory placode with a quail olfactory placode. Our results indicate that the olfactory placode is critical for olfactory bulb development, but is not necessary for the development of the rest of the telencephalon. Further, our results support the hypothesis that LHRH neurons and olfactory nerve glia originate in the olfactory placode, but do not support an olfactory placodal origin for other cell types within the olfactory bulb. © 2001 John Wiley & Sons, Inc. J Neurobiol 49: 29–39, 2001