Proteinase-mediated insect resistance to Bacillus thuringiensis toxins
Proteinase-mediated insect resistance to Bacillus thuringiensis toxins
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DOI：
10.1074/jbc.272.38.23473
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发表时间：
1997-09-19
影响因子：
4.8
通讯作者：
McGaughey, WH
中科院分区：
文献类型：
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作者：
Oppert, B;Kramer, KJ;McGaughey, WH
两种苏云金芽孢杆菌（Bt）抗性菌株的印度谷蛾，Plodia interpunctella，缺乏一个主要的肠道蛋白酶，激活Bt原毒素。这种酶的缺乏与Bt处理的饮食中的幼虫存活有遗传联系。当考虑与以前的数据支持受体介导的昆虫对Bt的抗性的存在，这些结果提供了证据，昆虫适应这些毒素发生通过多种生理机制，这复杂的努力，以防止或管理Bt毒素的抗性昆虫控制程序。
Two Bacillus thuringiensis (Bt)-resistant strains of the Indianmeal moth, Plodia interpunctella, lack a major gut proteinase that activates Bt protoxins. The absence of this enzyme is genetically linked to larval survival on Bt-treated diets. When considered with previous data supporting the existence of receptor-mediated insect resistance to Bt, these results provide evidence that insect adaptation to these toxins occurs through multiple physiological mechanisms, which complicate efforts to prevent or manage resistance to Bt toxins in insect control programs.