Endogenous opioid receptor genes and alcohol dependence among Taiwanese Han
Endogenous opioid receptor genes and alcohol dependence among Taiwanese Han
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DOI：
10.1097/01.alc.0000106303.41755.b8
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发表时间：
2004-01-01
影响因子：
3.2
通讯作者：
Cheng, ATA
中科院分区：
文献类型：
--
作者：
Loh, EW;Fann, CSJ;Cheng, ATA
背景：在不同的实验条件下，非选择性阿片受体拮抗剂可以减少酒精摄入量，一些关联研究已经检测了阿片受体Mu(OPRM)、Delta(OprD)和kappa(OPRK)基因在酒精依赖形成中的可能作用。方法：我们检测了158名酒精依赖者和149名对照的OPRM、OprD和OPRK基因上的20个单核苷酸多态(SNPs)。结果：病例组和对照组的等位基因频率和基因型频率均无显著差异。结论：我们的研究结果不支持阿片受体基因在台湾汉族人酒精依赖倾向中的可能作用。
Background: Nonselective opioid antagonists reduce alcohol consumption under various experimental situations, and several association studies have examined possible roles of opioid receptor mu (OPRM), delta (OPRD), and kappa (OPRK) genes in the development of alcohol dependence.Methods: We examined 20 single nucleotide polymorphisms (SNPs) across the OPRM, OPRD, and OPRK genes in 158 alcohol-dependent subjects and 149 controls. Differences in allele frequency and genotype distribution between case subjects and controls, as well as the deviation from Hardy-Weinberg equilibrium, were examined using Fisher's exact tests.Results: No significant difference in either allele or genotype frequency was found between case subjects and controls for each of the SNPs.Conclusions: Our findings do not support a possible role of the opioid receptor genes for the proclivity to alcohol dependence in the Taiwanese Han.