Urinary connective tissue growth factor excretion in patients with type 1 diabetes and nephropathy
Urinary connective tissue growth factor excretion in patients with type 1 diabetes and nephropathy
复制标题
DOI：
10.2337/diacare.26.9.2632
复制
发表时间：
2003-09-01
期刊：
影响因子：
16.2
通讯作者：
Jerums, G
中科院分区：
文献类型：
--
作者：
Gilbert, RE;Akdeniz, A;Jerums, G
以蛋白尿肾病为特征的肾小管间质疾病的发生。在这一横断面研究中，我们试图研究尿排泄的促纤维化细胞因子结缔组织生长因子（CTGF）在I型糖尿病患者的初期和明显的糖尿病nephropathy.Research设计和方法-我们招募了31例受试者与I型糖尿病从医院糖尿病门诊。其中，10例受试者为正常白蛋白尿，8例为微量白蛋白尿且未接受ACE抑制剂治疗，13例为大量白蛋白尿，其中8例接受ACE抑制剂治疗。结果：尿CTGF-N与蛋白尿程度密切相关（r = 0.76，P <0.001），尿CTGF-N与尿肌酐呈显著正相关（r = 0.76，P < 0.001）。与正常白蛋白尿受试者相比，微量白蛋白尿和未经治疗的大量白蛋白尿受试者的尿CTGF-N分别增加10倍和100倍。（CTGF-N-与-肌酸酐比率：正常白蛋白尿0.23 X/ml 1.3 ng/mg，微量白蛋白尿2.1 X/ml 1.7 ng/mg，未治疗的大量白蛋白尿203 X/ml 3.8 ng/mg，和几何平均X/ml耐受因子;正常白蛋白尿与微量白蛋白尿的P < 0.05，微量白蛋白尿与大量白蛋白尿的P < 0.001）。尿CTGF-N较低（
genesis of tubulointerstitial disease that characterizes proteinuric renal disease. In this cross-sectional study, we sought to examine the urinary excretion of the profibrotic cytokine connective tissue growth factor (CTGF) in type I diabetic patients with incipient and overt diabetic nephropathy.RESEARCH DESIGN AND METHODS - We recruited 31 subjects with type I diabetes from a hospital diabetes outpatient clinic. Of these, 10 subjects were normoalbuminuric, 8 were microalbuminuric and not receiving ACE inhibitor treatment, and 13 were macroalbuminuric, 8 of whom were receiving ACE inhibitor treatment. Urinary CTGF NH2-terminal fragment (CTGF-N) was determined by enzyme-linked immunosorbent assay and expressed relative to urinary creatinine.RESULTS - Urinary CTGF-N was closely correlated with the degree of albuminuria (r = 0.76, P < 0.001). In comparison with normoalbuminuric subjects, urinary CTGF-N was increased 10- and 100-fold in micro- and untreated macroalbuminuric subjects, respectively (CTGF-N-to-creatinine ratio: normoalbuminuria 0.23 X/÷ 1.3 ng/mg, microalbuminuria 2.1 X/÷ 1.7 ng/mg, untreated macroalbuminuria 203 X/÷ 3.8 ng/mg, and geometric mean X/÷ tolerance factor; P < 0.05 for normoalbuminuria versus microalbuminuria, P < 0.001 for microalbuminuria versus macroalbuminuria). Urinary CTGF-N was lower (