Upstream and downstream targets of RUNX proteins
Upstream and downstream targets of RUNX proteins
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DOI：
10.1002/jcb.10491
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发表时间：
2003-05-01
影响因子：
4
通讯作者：
Stock, M
中科院分区：
文献类型：
--
作者：
Otto, F;Lübbert, M;Stock, M
近年来，RUNX转录因子家族的三个成员在体内的作用已经部分阐明。虽然RUNX1对于成熟的造血是必不可少的，而Runx2对于骨软骨的形成是必不可少的，而Runx3在神经系统中具有一定的功能。影响RUNX1基因的易位和突变显然与白血病的发生有关，而最近的数据表明，RUNX3表达水平的变化可能参与了胃癌的发生。在一种常染色体显性遗传性骨骼疾病--锁骨颅骨发育不良的患者中发现了RUNX2的胚系突变。虽然已经描述了许多调节RUNX活性的途径，但结合RUNX启动子的转录因子才刚刚开始被识别。越来越多的基因被描述为在转录活动中受到不同RUNX蛋白调控的基因。一个特定的RUNX蛋白是否特定地针对下游基因的一个子集，或者关于哪个RUNX蛋白激活哪个靶基因启动子是否存在一些冗余，仍有待阐明。(C)2003年Wiley-Liss，Inc.
In recent years, the in vivo role of the three members of the RUNX family of transcription factors has in part been elucidated. While Runx1 is essential for mature haematopoiesis and Runx2 for osteochondrogenesis, Runx3 has a function in the nervous system. Translocations and mutations affecting the RUNX1 gene are clearly implicated in leukernogenesis whereas recent data suggest that changed expression levels of RUNX3 may be involved in gastric carcinogenesis. Germ line mutations in RUNX2 have been identified in patients with an autosomal dominant skeletal disorder, cleidocranial dysplasia. While a number of pathways have been delineated that regulate RUNX activity, transcription factors binding to RUNX promoters are only beginning to be identified. A growing number of genes have been characterised that are being regulated in their transcriptional activity by different RUNX proteins. Whether a particular RUNX protein specifically targets a defined subset of downstream genes or whether there is some redundancy as to which RUNX protein activates which target promoter remains to be elucidated. (C) 2003 Wiley-Liss, Inc.