The role of immunoglobulin E in allergy and asthma
The role of immunoglobulin E in allergy and asthma
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DOI：
10.1164/ajrccm.164.supplement_1.2103024
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发表时间：
2001-10-15
影响因子：
24.7
通讯作者：
Platts-Mills, TAE
中科院分区：
文献类型：
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作者：
Platts-Mills, TAE
自首次提出血浆或血清中的可溶性因子可能导致过敏性疾病和哮喘症状以来，已有近一个世纪；自免疫球蛋白E （IgE）被确定为介导现在所描述的1型超敏反应（过敏性哮喘、过敏性鼻炎、食物过敏、特应性皮炎、某些形式的药物过敏和昆虫叮咬过敏）的关键分子以来，已有30多年。从那时起，过敏和哮喘的炎症级联的许多细节已经被阐明，IgE现在被认为起着关键的上游作用。本报告的目的是回顾由IgE启动的细胞和分子事件，并检查其参与皮肤和肺部的即时过敏反应和晚期或慢性炎症反应的证据。
it has been nearly a century since the first suggestion that a soluble factor in plasma or serum might be responsible for the symptoms of allergic disease and asthma, and more than 30 yr since immunoglobulin E (IgE) was identified as the key molecule in mediating what are now described as type 1 hypersensitivity reactions (allergic asthma, allergic rhinitis, food allergy, atopic dermatitis, some forms of drug allergy, and insect sting allergy). Since that time, many of the details of the inflammatory cascade underlying allergy and asthma have been elucidated, and IgE is now known to play a key upstream role. The goals of this report are to review the cellular and molecular events set in motion by IgE and to examine the evidence for its participation in both the immediate allergic response and the late-phase or chronic inflammatory response in the skin and lungs.