Ultrasound mediated destruction of DNA-loaded microbubbles for enhancement of cell-based therapies: new promise amidst a confluence of uncertainties?
Ultrasound mediated destruction of DNA-loaded microbubbles for enhancement of cell-based therapies: new promise amidst a confluence of uncertainties?
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DOI：
10.1016/j.jcmg.2009.05.006
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发表时间：
2009-07
期刊：
影响因子：
--
通讯作者：
F. Villanueva
中科院分区：
文献类型：
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作者：
F. Villanueva
目前临床使用的超声造影剂是小的（1至4 μm）充满气体的“微泡”，由全氟碳气体组成，由生物相容性外壳封装(1)。它们自由地通过微循环；高功率超声波可以选择性地破坏这些微泡，随后将其内容物释放到感兴趣的器官中。微气泡的这种声学响应性已经被利用，
Ultrasound contrast agents in current clinical use are small (1 to 4 μm) gas-filled “microbubbles” comprised of a perfluorocarbon gas that is encapsulated by a biocompatible shell (1). They freely transit through the microcirculation; high-powered ultrasound can be used to selectively destroy these microbubbles, with consequent release of their contents into the organ of interest. This acoustic responsiveness of microbubbles has been exploited,