Evolution of Efficient Strategies for Enone-Alkyne and Enal-Alkyne Reductive Couplings
Evolution of Efficient Strategies for Enone-Alkyne and Enal-Alkyne Reductive Couplings
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DOI：
10.1021/ja9083607
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发表时间：
2009-11-25
影响因子：
15
通讯作者：
Montgomery, John
中科院分区：
文献类型：
--
作者：
Li, Wei;Herath, Ananda;Montgomery, John
已经开发了用于烯酮或烯醛与炔的还原偶联的策略。所用的还原剂包括有机锌、有机硼烷、有机硅烷和甲醇。这些策略中的后者是简单的，具有成本效益的，并且容忍许多官能团。同位素标记策略为机制建议提供了支持证据。
Strategies for the reductive coupling of enones or enals with alkynes have been developed. The reducing agents employed include organozincs, organoboranes, organosilanes, and methanol. The latter of these strategies is simple, cost-effective, and tolerant of many functional groups. Isotopic labeling strategies have provided supporting evidence for the mechanistic proposals.