Stem cell dynamics in the hair follicle niche.
Stem cell dynamics in the hair follicle niche.
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DOI：
10.1016/j.semcdb.2013.12.005
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发表时间：
2014-01
影响因子：
7.3
通讯作者：
Greco, Valentina
中科院分区：
文献类型：
--
作者：
Rompolas, Panteleimon;Greco, Valentina
毛囊是哺乳动物皮肤的附属物，具有周期性和典型的再生能力，以便在我们的一生中不断产生新的头发。毛囊的再生能力是由于干细胞的存在，以及其他细胞群和非细胞成分，包括分子信号和细胞外物质，构成了一个生态位微环境。越来越多的证据表明，生态位对调节干细胞行为和再生过程至关重要。在这里，我们回顾了过去和现在的研究文献，这些研究利用小鼠遗传模型，结合其他方法来解剖毛囊生态位的分子和细胞组成。我们还讨论了我们目前对干细胞在组织再生过程中如何在生态位内运作以及调节其行为的因素的理解。
Hair follicles are skin appendages of the mammalian skin that have the ability to periodically and stereotypically regenerate in order to continuously produce new hair over our lifetime. The ability of the hair follicle to regenerate is due to the presence of stem cells that along with other cell populations and non-cellular components, including molecular signals and extracellular material, make up a niche microenvironment. Mounting evidence suggests that the niche is critical for regulating stem cell behavior and thus the process of regeneration. Here we review the literature concerning past and current studies that have utilized mouse genetic models, combined with other approaches to dissect the molecular and cellular composition of the hair follicle niche. We also discuss our current understanding of how stem cells operate within the niche during the process of tissue regeneration and the factors that regulate their behavior.
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影响因子：
23.9
作者：
Fuchs E
通讯作者：
Fuchs E
影响因子：
64.5
作者：
Fujiwara H;Ferreira M;Donati G;Marciano DK;Linton JM;Sato Y;Hartner A;Sekiguchi K;Reichardt LF;Watt FM
通讯作者：
Watt FM
影响因子：
64.8
作者：
Chang, Chiung-Ying;Pasolli, H. Amalia;Giannopoulou, Eugenia G.;Guasch, Geraldine;Gronostajski, Richard M.;Elemento, Olivier;Fuchs, Elaine
通讯作者：
Fuchs, Elaine
影响因子：
23.9
作者：
Brownell, Isaac;Guevara, Elizabeth;Bai, C. Brian;Loomis, Cynthia A.;Joyner, Alexandra L.
通讯作者：
Joyner, Alexandra L.
影响因子：
4.8
作者：
Foitzik, K;Lindner, G;Paus, R
通讯作者：
Paus, R