Development of Biodegradable Starch Microspheres for Intranasal Delivery
Development of Biodegradable Starch Microspheres for Intranasal Delivery
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用于鼻内递送的可生物降解淀粉微球的开发
DOI：
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发表时间：
2008
影响因子：
0.5
通讯作者：
HH Mote
中科院分区：
文献类型：
--
作者：
AV Yadav;HH Mote
采用乳化交联技术制备了多潘立酮鼻腔给药微球。淀粉是一种可生物降解的聚合物，以环氧氯丙烷为交联剂制备微球。以药物浓度和聚合物浓度为处方变量，制备了一批无药物微球进行比较。对所有处方的颗粒大小、形态特征、药物包封率、平衡溶胀度、黏附率、生物黏附强度以及鼻腔细胞体外扩散实验进行了评价。所有批次的微球均为球形，平均粒径在22.8~102.63μm之间，具有良好的黏附性能和溶胀性能。体外释放度在73.11%~86.21%之间。聚合物浓度和药物浓度都会影响药物的体外释放。
Domperidone microspheres for intranasal administration were prepared by emulsification crosslinking technique. Starch a biodegradable polymer was used in preparation of microspheres using epichlorhydrine as cross-linking agent. The formulation variables were drug concentration and polymer concentration and batch of drug free microsphere was prepared for comparisons. All the formulations were evaluated for particle size, morphological characteristics, percentage drug encapsulation, equilibrium swelling degree, percentage mucoadhesion, bioadhesive strength, and in vitro diffusion study using nasal cell. Spherical microspheres were obtained in all batches with mean diameter in the range of above 22.8 to 102.63 μm. They showed good mucoadhesive property and swelling behaviour. The in vitro release was found in the range of 73.11% to 86.21%. Concentration of both polymer and drug affect in vitro release of drug.