Co-expression of CD133, CD44v6 and human tissue factor is associated with metastasis and poor prognosis in pancreatic carcinoma
Co-expression of CD133, CD44v6 and human tissue factor is associated with metastasis and poor prognosis in pancreatic carcinoma
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CD133、CD44v6和人组织因子的共表达与胰腺癌转移和不良预后相关
DOI：
10.3892/or.2014.3245
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发表时间：
2014-08-05
期刊：
影响因子：
4.2
通讯作者：
Li, Xiaowu
中科院分区：
文献类型：
--
作者：
Chen, Kai;Li, Zhonghu;Li, Xiaowu
转移相关分子CD 133、CD 44v6和人组织因子（TF）与肿瘤的侵袭和转移有关。本研究旨在确定这三种分子的共表达是否与胰腺癌的转移和总体预后相关。我们通过免疫组织化学方法分析了这三种分子的表达谱，并评估了它们的表达谱与109例胰腺癌转移和预后的关系。结果显示，胰腺癌组织中CD 133、CD 44v6和TF表达水平均增高。胰腺癌组织中CD 133、CD 44v6和TF共表达（三重表达）。CD133、CD44v6和TF的单独表达与血管浸润、淋巴结转移和肝转移有关，三者联合表达与淋巴结转移有关。生存分析显示，CD133和TF共表达或三重表达的患者的总生存率分别较低和最低。单因素分析显示T细胞因子、淋巴结转移、TNM分期、CD133、CD44v6和TF的表达水平是影响患者生存的危险因素。多因素分析显示，CD133、CD44v6和TF三者联合表达是生存的独立预测因子。提示CD 133、CD 44v6和TF的过度表达与胰腺癌的转移有关。这三种分子的TR表达可能是胰腺癌预后的有用预测因子。
The metastasis-related molecules CD133, CD44v6 and human tissue factor (TF) have been shown to be associated with tumor invasion and metastasis. This study aimed to determine whether co-expression of these three molecules was associated with metastasis and overall prognosis in pancreatic carcinoma. We analyzed the expression profiles of these three molecules by immunohistochemistry and evaluated the relationship of their expression profiles with metastasis and prognosis in 109 pancreatic carcinomas. The results showed that the expression levels of CD133, CD44v6 and TF were increased in pancreatic carcinoma. Co-expression of CD133, CD44v6 and TF (tri-expression) was also detected in pancreatic carcinoma. Clinical analysis showed that individual expression of CD133, CD44v6 or TF was associated with vessel invasion, lymph node metastasis and liver metastasis, while tri-expression was associated with lymph node metastasis. Survival analysis showed that patients with co-expression of CD133 and TF or tri-expression had lower and the lowest overall survival rates, respectively. Univariate analysis showed that T-factor, lymph node metastasis, TNM stage, and individual levels or tri-expression of CD133, CD44v6 and TF were survival risk factors. Multivariate analysis showed that tri-expression of CD133, CD44v6 and TF was an independent predictor of survival. These results suggest that overexpression of CD133, CD44v6 and TF is associated with pancreatic carcinoma metastasis. Tr-expression of these three molecules may be a useful predictor for pancreatic carcinoma prognosis.