Novel Strategy for Synthesis of Substituted Benzimidazo[1,2-a]quinolines
Novel Strategy for Synthesis of Substituted Benzimidazo[1,2-a]quinolines
复制标题
DOI：
10.1021/ol4017723
复制
发表时间：
2013-07-19
期刊：
影响因子：
5.2
通讯作者：
Yokomatsu, Tsutomu
中科院分区：
文献类型：
--
作者：
Kato, Jun-ya;Ito, Yutaro;Yokomatsu, Tsutomu
通过芳香族亲核取代和分子内Knoevenagel缩合反应的级联反应，发展了一种在无过渡金属条件下合成苯并咪唑并[1，2-a]喹啉类化合物的有效方法.该方法适用于从容易获得的2-氟芳基醛和苯并咪唑底物合成宽范围的苯并咪唑并[1，2-a]喹啉衍生物。
An efficient method for the synthesis of benzimidazo[1,2-a]quinolines under transition-metal-free conditions has been developed through a cascade reaction involving sequential aromatic nucleophilic substitution and intramolecular Knoevenagel condensation reactions. This method is applicable for the synthesis of a wide range of benzimidazo[1,2-a]quinoline derivatives from readily available 2-fluoroarylaldehyde and benzimidazole substrates.