Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization
Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization
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DOI：
10.1053/j.gastro.2020.05.048
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发表时间：
2020-09-01
期刊：
影响因子：
29.4
通讯作者：
Ng, Siew C.
中科院分区：
文献类型：
--
作者：
Zuo, Tao;Zhang, Fen;Ng, Siew C.
背景与目的：尽管严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染胃肠道组织，但对肠道微生物在感染易感性和严重性中的作用知之甚少。我们调查了SARS-CoV-2感染患者住院期间粪便微生物组的变化以及与病毒严重程度和粪便脱落的相关性。方法：我们于2020年2月5日至3月17日对香港15名2019冠状病毒病（COVID-19）患者的粪便样本进行了鸟枪宏基因组测序分析。从住院到出院，每周采集2或3次粪便样本;疾病分为轻度（无肺炎的放射学证据）、中度（存在肺炎）、重度（呼吸频率>= 30/min，或氧饱和度）
BACKGROUND & AIMS: Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects gastrointestinal tissues, little is known about the roles of gut commensal microbes in susceptibility to and severity of infection. We investigated changes in fecal microbiomes of patients with SARS-CoV-2 infection during hospitalization and associations with severity and fecal shedding of virus. METHODS: We performed shotgun metagenomic sequencing analyses of fecal samples from 15 patients with Coronavirus Disease 2019 (COVID-19) in Hong Kong, from February 5 through March 17, 2020. Fecal samples were collected 2 or 3 times per week from time of hospitalization until discharge; disease was categorized as mild (no radiographic evidence of pneumonia), moderate (pneumonia was present), severe (respiratory rate >= 30/min, or oxygen saturation