Rhodiola:: A promising anti-aging Chinese Herb
Rhodiola:: A promising anti-aging Chinese Herb
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DOI：
10.1089/rej.2007.0560
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发表时间：
2007-12-01
影响因子：
2.6
通讯作者：
Mueller, Laurence D.
中科院分区：
文献类型：
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作者：
Jafari, Mahtab;Felgner, Jeffrey S.;Mueller, Laurence D.
以果蝇为实验对象，研究了红景天对果蝇寿命的影响。红景天是一种用于中药的植物根，可以增加生物体对压力的抵抗力。有人提出，红景天可以延长寿命，改善健康寿命，减轻氧化应激。每隔一天提供30 mg/mL的红景天显著延长了果蝇的寿命。当比较添加红景天的果蝇和对照果蝇之间的死亡分布时，喂食红景天的果蝇表现出衰老减慢。尽管观察到的寿命延长与生育力的统计学上不显著的降低相关，但校正可能的饮食限制效应仍然没有消除补充和对照果蝇之间的差异，红景天的效应也不依赖于饮食操作，这强烈表明红景天不仅仅是饮食限制模拟物。虽然这项研究没有揭示红景天效果背后的因果机制，但它确实表明该补充剂值得继续研究，不像本研究中评估的其他中草药，鹿多味（LDW），补中益气汤（BZYQT），三芝片（SZP，三个帝国蘑菇），红景天（红景天）。
Using the fruit fly, Drosophila melanogaster, we investigated the effects of Rhodiola on life-span. Rhodiola is a plant root used in traditional Chinese medicine that may increase an organism's resistance to stress. It has been proposed that Rhodiola can extend longevity and improve health span by alleviating oxidative stress. Rhodiola supplied every other day at 30 mg/mL significantly increased the lifespan of Drosophila melanogaster. When comparing the distribution of deaths between Rhodiola-supplemented and control flies, Rhodiola-fed flies exhibited decelerated aging. Although the observed extension in lifespan was associated with statistically insignificant reductions in fecundity, correcting for a possible dietary restriction effect still did not eliminate the difference between supplemented and control flies, nor does the effect of Rhodiola depend on dietary manipulation, strongly suggesting that Rhodiola is not a mere dietary restriction mimetic. Although this study does not reveal the causal mechanism behind the effect of Rhodiola, it does suggest that the supplement is worthy of continued investigation, unlike the other Chinese herbals, Lu Duo Wei (LDW), Bu Zhong Yi Qi Tang (BZYQT), San Zhi Pian (SZP, Three Imperial Mushrooms), Hong Jing Tian (Rhodiola) that were evaluated in this study.