On the conflict between precision and robustness in the proportion regulation of cell types
On the conflict between precision and robustness in the proportion regulation of cell types
复制标题
论细胞类型比例调控精度与鲁棒性的矛盾
DOI：
--
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Y. Sawada
中科院分区：
文献类型：
--
作者：
Ismael Rafols;H. Macwilliams;Y. Maeda;Y. Sawada
在盘基网柄藻中，已知细胞类型的比例受到主动调节，例如在去除给定细胞类型后恢复。然而，我们最近表明，监管本质上是不精确的：它控制高于/低于某些上限和下限阈值的比例，但不在这些阈值定义的允许范围内。为了解释这一发现，我们提出了一个模型的基础上（i）一个全球性的负反馈，和（ii）一个细胞自主的正反馈，导致一个类似的行为（即细胞类型的双稳态）。模拟的细胞类型的比例确实被发现跨越一个范围的值作为双稳态的结果。我们的结论是，比例调节的精度和细胞类型分化的鲁棒性之间存在普遍的冲突。
In Dictyostelium discoideum the proportion of cell types is known to be actively regulated, recovering, for example, after the removal of a given cell type. However, we have recently shown that regulation is intrinsically imprecise: it controls the proportion above/below certain upper and lower thresholds, but not within an allowed range of values that these thresholds define. To explain this finding we present a model based on (i) a global negative feedback, and (ii) a cell-autonomous positive feedback leading to a hysteresis-like behaviour (i.e, a bistability of cell type). The simulated cell-type proportion is indeed found to span a range of values as a consequence of the bistability. We conclude that there is a general conflict between the precision of proportion regulation and the robustness of the differentiation of cell types.