Early osmoregulatory stimulation of neurohypophyseal hormone secretion and thirst after gastric NaCl loads.
Early osmoregulatory stimulation of neurohypophyseal hormone secretion and thirst after gastric NaCl loads.
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DOI：
10.1152/ajpregu.00548.2001
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发表时间：
2002-06
期刊：
影响因子：
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通讯作者：
E. Stricker;J. B. Callahan;Wan Huang;A. Sved
中科院分区：
文献类型：
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作者：
E. Stricker;J. B. Callahan;Wan Huang;A. Sved
脑渗透受体通过血浆有效渗透压（P(osmol)）的增加来调节口渴和神经垂体分泌。本实验确定了胃内高渗盐水（ig HS; 0.5 M NaCl, 4 ml）是否会在大脑渗透受体检测到全身循环中P（osmol）的增加之前增强这些反应。成年大鼠在被剥夺水分过夜后再灌胃HS，在15-30分钟内消耗的水比单独进行预处理的大鼠要多得多，尽管全身P（osmol）尚未因胃负荷而显著增加。在静脉输注1 M NaCl （2 ml/h，持续2 h）预处理的其他大鼠中，胃内注射HS后15和25分钟，血浆加压素和催产素水平显著升高，而全身P（osmol）没有进一步升高。这些和其他研究结果与先前的报道一致，即在给予胃NaCl负荷的脱水大鼠中，肝门脉渗透受体（或Na（+）受体）刺激口渴和神经垂体激素分泌，并表明这些作用在动物脱水时增强。
Cerebral osmoreceptors mediate thirst and neurohypophyseal secretion stimulated by increases in the effective osmolality of plasma (P(osmol)). The present experiments determined whether an intragastric load of hypertonic saline (ig HS; 0.5 M NaCl, 4 ml) would potentiate these responses before induced increases in P(osmol) in the general circulation could be detected by cerebral osmoreceptors. Adult rats deprived of water overnight and then given intragastric HS consumed much more water in 15-30 min than rats given either pretreatment alone, even though systemic P(osmol) had not yet increased significantly because of the gastric load. In other rats pretreated with an intravenous infusion of 1 M NaCl (2 ml/h for 2 h), plasma levels of vasopressin and oxytocin were considerably elevated 15 and 25 min after intragastric HS treatment, whereas systemic P(osmol) was not increased further. These and other findings are consistent with previous reports that hepatic portal osmoreceptors (or Na(+) receptors) stimulate thirst and neurohypophyseal hormone secretion in euhydrated rats given gastric NaCl loads and indicate that these effects are potentiated when animals are dehydrated.