Effects of fine particulate matter (PM2.5) on ovarian function and embryo quality in mice
Effects of fine particulate matter (PM2.5) on ovarian function and embryo quality in mice
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细颗粒物（PM2.5）对小鼠卵巢功能和胚胎质量的影响
DOI：
10.1016/j.envint.2019.105338
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发表时间：
2020-02-01
影响因子：
11.8
通讯作者：
Wang, Hai-Long
中科院分区：
文献类型：
--
作者：
Liao, Bao-Qiong;Liu, Chao-Bin;Wang, Hai-Long
细颗粒物（PM2.5）对生殖功能有不利影响，特别是导致男性生殖功能下降，但相对较少的研究直接针对其对女性生殖的影响。为了探讨PM（2.5）暴露对雌性生殖的影响，我们通过气管内滴注将雌性小鼠暴露于PM（2.5）28天，并评估受精后卵巢颗粒细胞和卵母细胞的凋亡以及胚胎质量。我们的研究结果显示，暴露于高浓度的PM2.5后，凋亡颗粒细胞和卵母细胞的数量增加，这通过损害胚胎发育和质量对女性生育力产生不利影响。我们的结论是，PM2.5诱导卵巢颗粒细胞和卵母细胞的凋亡，导致破坏胚胎发育和雌性小鼠的生育能力。
Fine particulate matter (PM2.5) has an adverse effect on reproductive function, in particular causing reduced male reproductive function, but relatively few studies have directly targeted its effects on female reproduction. To investigate the effects of PM(2.5 )exposure on female reproduction, we exposed female mice to PM2.5 by intratracheal instillation for 28 days, and evaluated apoptosis of ovarian granulosa cells and oocytes and the quality embryos after insemination. Our results showed increased numbers of apoptotic granulosa cells and oocytes after exposure to elevated concentrations of PM2.5, which had adverse effects on female fertility via compromising embryo development and quality. We conclude that PM2.5 induced apoptosis of ovarian granulosa cells and oocytes leading to disrupted embryo development and female fertility in mice.