Tracer Kinetic Modeling in PET
Tracer Kinetic Modeling in PET
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DOI：
10.1016/j.cpet.2007.08.003
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发表时间：
2007-04-01
期刊：
影响因子：
2.6
通讯作者：
Zaidi, Habib
中科院分区：
文献类型：
--
作者：
Bentourkia, M'hamed;Zaidi, Habib
利用PET进行分子成像为非侵入性研究活体器官的生物化学提供了一种独特的工具。广泛的放射性标记分子使得在体内探索各种生化、生理和药理过程成为可能。由于每一种放射性示踪剂在人体内都有其独特的动力学行为，因此对这种行为的量化是改进成像方案和快速将研究和开发转化为临床的关键组成部分。需要合适的图像重建算法与示踪剂动力学建模技术相结合来从可用的四维图像中评估参数或定量的生物图像。通常使用适当的数学模型来拟合感兴趣区域或体积的时间-活动曲线，从而允许评估生物参数。
Molecular imaging using PET provides a unique tool for noninvasively investigating the biochemistry of living organs. The wide range of radiolabeled molecules makes it possible to explore various biochemical, physiologic, and pharmacologic processes in vivo. Because each radiotracer is characterized by its particular kinetic behavior in the human body, the quantification of this behavior is a critical component for the improvement of imaging protocols and for rapid translation from research and development to the clinic. Suitable image reconstruction algorithms combined with tracer kinetic modeling techniques are needed to assess parametric or quantitative biologic images from the available fourdimensional images. An appropriate mathematical model is generally used to fit the time-activity curves of a region or volume of interest, thus allowing the assessment of biologic parameters.