DISC1 as a Possible Genetic Contribution to Opioid Dependence in a Polish Sample.
DISC1 as a Possible Genetic Contribution to Opioid Dependence in a Polish Sample.
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DOI：
10.15288/jsad.2016.77.220
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发表时间：
2016-03
影响因子：
3.4
通讯作者：
Sylwia Fudalej;A. Jakubczyk;M. Kopera;J. Piwoński;Wojciech Bielecki;W. Drygas;Krystyna Wasilewska;M. Ilgen;A. Bohnert;K. Barry;R. Płoski;F. Blow;M. Wojnar
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文献类型：
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作者：
Sylwia Fudalej;A. Jakubczyk;M. Kopera;J. Piwoński;Wojciech Bielecki;W. Drygas;Krystyna Wasilewska;M. Ilgen;A. Bohnert;K. Barry;R. Płoski;F. Blow;M. Wojnar
目的精神分裂症1型（DISC 1）与多种精神疾病和神经精神表型的易感性有关。然而，DISC 1并没有经常被检查为药物依赖的潜在风险因素。阿片类药物依赖和DISC 1 rs 2738888多态性之间的关联最近已被报道。此外，阿片类药物依赖与rs6419156相关，rs6419156位于蛋白磷酸酶3催化亚基α亚型（PPP 3CA）基因附近。本研究的目的是在一个独立的样本中检查阿片类药物依赖与rs 2738888和rs6419156之间的关联。方法选择的多态性基因分型的392个人（69.9%男性）诊断为酒精和/或阿片类药物依赖的样本。对照组（n = 257; 67.7%男性）来自波兰国家健康调查（N = 14，350）。结果：对照组rs 2738888 C等位基因频率高于阿片类药物依赖组（OR = 0.65，p = 0.045）。在阿片类药物依赖个体中进行的表型导向分析揭示了终身自杀企图与rs 2738888之间的关联。rs 2738888的C等位基因对阿片类药物依赖患者的终身自杀企图具有保护作用（OR = 0.25，p = .003）。Rs6419156与检查样本中的物质依赖无关。结论DISC 1可能在阿片依赖易感性中起重要作用。此外，DISC 1也可能是阿片类药物依赖者自杀未遂的遗传风险因素。
OBJECTIVE Disrupted-in-schizophrenia 1 (DISC1) has been linked to vulnerability to a variety of psychiatric disorders and neuropsychiatric phenotypes. However, DISC1 has not been frequently examined as a potential risk factor for substance dependence. An association between opioid dependence and DISC1 rs2738888 polymorphism has been recently reported. In addition, opioid dependence was associated with rs6419156 located close to the protein phosphatase 3 catalytic subunit alpha isoform (PPP3CA) gene. The aim of the present study was to examine the associations between opioid dependence with rs2738888 and rs6419156 in an independent sample. METHOD The selected polymorphisms were genotyped in a sample of 392 individuals (69.9% male) diagnosed as alcohol- and/or opioid-dependent. A control group (n = 257; 67.7% male) was derived from the Polish National Health Survey (N = 14,350). RESULTS The frequency of rs2738888 C allele was higher in controls than in opioid-dependent cases (OR = 0.65, p = .045). Phenotypic-oriented analyses performed within opioid-dependent individuals revealed the association between lifetime suicide attempt and rs2738888. The C allele of rs2738888 had a protective effect on lifetime suicide attempt in opioid-dependent patients (OR = 0.25, p = .003). Rs6419156 was not associated with substance dependence in the examined sample. CONCLUSIONS The DISC1 may play an important role in vulnerability to opioid dependence. In addition, DISC1 may also be a genetic risk factor for suicide attempt in opioid-dependent individuals.