Genotoxic activity of benomyl in different test systems
Genotoxic activity of benomyl in different test systems
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不同测试系统中苯菌灵的基因毒性活性
DOI：
10.1002/em.2850160106
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发表时间：
1990
影响因子：
2.8
通讯作者：
Dr. A. Kappas
中科院分区：
文献类型：
--
作者：
V. Georgieva;R. Vachkova;M. Tzoneva;A. Kappas;Dr. A. Kappas
Benomyl (methyl‐1‐[butylcarbamoyl]‐2‐benzimidozole carbamate), a benzimidazole derivative fungicide, was tested in the Ames test for point mutations; in human lymphocyte cultures for cell division disturbances, chromosomal aberrations, and SCE; in rat bone marrow cells in vivo for micronuclei; and in rats in vivo for dominant lethals. Benomyl was negative in the Ames test. In human lymphocytes, benomyl at concentrations of 0.5, 1.0, and 2.0 μg/ml decreased the number of cells undergoing third division whereas at the concentrations of 0.25 to 4.0 μg/ml it strongly increased the number of aneuploid cells. Benomyl was also shown to induce sister chromatid exchanges and micronuclei but not chromosome aberrations. Benomyl decreased the number of female rats with implants but did not cause any dominant lethals.
