Associations of mismatch negativity with psychotic symptoms and functioning transdiagnostically across psychotic disorders.
Associations of mismatch negativity with psychotic symptoms and functioning transdiagnostically across psychotic disorders.
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DOI：
10.1037/abn0000506
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发表时间：
2020-08
影响因子：
4.6
通讯作者：
Mohanty, Aprajita
中科院分区：
文献类型：
--
作者：
Donaldson, Kayla R;Novak, Keisha D;Foti, Dan;Marder, Maya;Perlman, Greg;Kotov, Roman;Mohanty, Aprajita
Mismatch negativity (MMN) amplitude has been widely shown to be diminished in schizophrenia and, more recently, in other psychotic disorders. While there is considerable evidence linking MMN reduction to cognitive and functional deficits in schizophrenia, there is little evidence of associations with specific psychotic symptoms. Further, it is unclear if MMN reductions relate to specific symptoms, cognitive, and functional deficits transdiagnostically across different psychotic disorders. The present study examines MMN amplitude in a large cohort of cases diagnosed with psychotic disorders including schizophrenia and schizoaffective disorder (N=116); bipolar disorder and major depressive disorder (N=75); and other psychotic disorders (N=25), as well as individuals with no psychotic disorder diagnoses (N=248). Furthermore, we examined the association of MMN with symptoms, cognitive functioning, and real-world functioning to determine whether these relationships differ by diagnosis. Results showed that MMN amplitude was reduced in cases overall compared to never-psychotic individuals, with no differences between psychotic disorders. Furthermore, there were transdiagnostic associations of reduced MMN-D with worse auditory hallucinations (r=.14) and disorganization (r=.14), MMN-F with real-word functioning (r=.20) and episodic memory (r=−.22), and both components with executive functioning (MMN-D: r= −.17; MMN-F: r= −.15). Our findings relating MMN reductions with cognitive and real-world functioning replicate earlier research in schizophrenia and extend these relationships to other psychotic disorders. Furthermore, our correlations with MMN-D are consistent with computational modeling research and theoretical proposals that view MMN reduction, cognitive dysfunction, and psychotic symptoms as reflecting underlying predictive coding deficits. However, differences in relationships with MMN-F suggest that additional work is warranted on this topic. Mismatch negativity (MMN) amplitude has been shown to be diminished in schizophrenia and other psychotic disorders. We show that MMN reductions are associated with worse auditory hallucinations, disorganization, as well as cognitive and real-world functioning transdiagnostically across psychotic disorders. These findings highlight the importance of MMN in tracking both symptom and functioning related impairment across psychosis-spectrum illnesses. Furthermore, associations with MMN-D are in line with theoretical and computational modeling research that attributes MMN reductions, cognitive dysfunction and psychotic symptoms to underlying predictive coding deficits, although importantly MMN-F findings could be argued to contradict a straightforward interpretation within the predictive coding model.
