A single nucleotide polymorphism in ADIPOQ predicts biochemical recurrence after radical prostatectomy in localized prostate cancer.
A single nucleotide polymorphism in ADIPOQ predicts biochemical recurrence after radical prostatectomy in localized prostate cancer.
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DOI：
10.18632/oncotarget.4980
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发表时间：
2015-10-13
期刊：
影响因子：
--
通讯作者：
Ye D
中科院分区：
文献类型：
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作者：
Gu C;Qu Y;Zhang G;Sun L;Zhu Y;Ye D
脂联素与前列腺癌（PCa）侵袭性有关。然而，脂联素（ADIPOQ）基因的遗传变异在前列腺癌进展中的作用尚不清楚。确定ADIPOQ基因变异是否与根治性前列腺切除术（RP）后生化复发（BCR）的风险相关。我们评估了728例接受RP的临床局限性PCa患者中三种常见的ADIPOQ多态性。采用多变量Cox比例风险模型和Kaplan-Meier分析评估其对BCR的预后意义。采用酶联免疫吸附法测定血浆脂联素浓度。ADIPOQ rs182052变异等位基因与BCR风险增加相关[HR: 2.44；95%可信区间（CI）： 1.57-3.79, P = 6×10−5)，脂联素水平降低（β =−0.048,P = 0.004）。分层分析表明，这种关联在内脏脂肪组织较高的男性中更为明显。我们的数据支持ADIPOQ rs182052 SNP可能通过改变脂联素水平的可能机制成为RP后BCR的预测性生物标志物。如果得到验证，遗传预测结果可能有助于PCa的个体化治疗。
Adiponectin has been implicated in prostate cancer (PCa) aggressiveness. However, the role of genetic variations in the adiponectin (ADIPOQ) gene in PCa progression remains unknown. To determine whether genetic variants in ADIPOQ are associated with the risk of biochemical recurrence (BCR) after radical prostatectomy (RP). We evaluated three common ADIPOQ polymorphisms in 728 men with clinically localized PCa who underwent RP. Multivariable Cox proportional hazards models and Kaplan–Meier analysis were used to assess their prognostic significance on BCR. The plasma adiponectin concentrations were measured by enzyme-linked immunosorbent assay. ADIPOQ rs182052 variant allele was associated with both increased risk of BCR [HR: 2.44; 95% confidence interval (CI): 1.57–3.79, P = 6×10−5] and decreased adiponectin level (β = −0.048, P = 0.004). Stratified analyses demonstrated that the association was more pronounced in men with higher visceral adipose tissue. Our data support that the ADIPOQ rs182052 SNP may be a predictive biomarker for BCR after RP by a possible mechanism of altering the adiponectin level. If validated, genetic predictors of outcome may help individualizing treatment for PCa.