Prevalence ofHelicobacter pylori resistance to several antimicrobial agents in a region of Germany
Prevalence ofHelicobacter pylori resistance to several antimicrobial agents in a region of Germany
复制标题
德国某地区幽门螺杆菌对多种抗菌药物耐药的流行情况
DOI：
10.1007/bf01691138
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发表时间：
1998
影响因子：
4.5
通讯作者：
Wolfgang König
中科院分区：
文献类型：
--
作者：
K. Wolle;M. Nilius;A. Leodolter;W. Müller;P. Malfertheiner;Wolfgang König
为评估德国幽门螺杆菌的耐药率，采用E试验方法测定了1996年和1997年271株幽门螺杆菌对阿莫西林、四环素、克拉霉素和甲硝唑的最低抑制浓度。甲硝唑耐药率为32.1%，女性耐药率(38.5%)高于男性(24.4%)。克拉霉素耐药罕见(3.3%)。9株克拉霉素耐药株中有8株对甲硝唑也耐药。十二指肠溃疡患者对甲硝唑或克拉霉素的耐药率显著升高(P=0.022)。未发现对阿莫西林或四环素耐药的菌株。
To evaluate the prevalence of resistance amongHelicobacter pyloriin Germany, the minimum inhibitory concentrations of amoxicillin, tetracycline, clarithromycin, and metronidazole were determined by means of the E test, for 271Helicobacter pyloriisolates cultured from biopsies taken during routine endoscopies in 1996 and 1997. The prevalence of metronidazole resistance was 32.1%, with resistance found more frequently in women (38.5%) than in men (24.4%). Clarithromycin resistance was rare (3.3%). Eight of nine strains resistant to clarithromycin were also resistant to metronidazole. Resistance to either metronidazole or clarithromycin was significantly (P=0.022) higher in patients with duodenal ulcer. No strain was found to be resistant to amoxicillin or tetracyline.