A novel histone deacetylase inhibitor Chidamide induces apoptosis of human colon cancer cells
A novel histone deacetylase inhibitor Chidamide induces apoptosis of human colon cancer cells
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DOI：
10.1016/j.bbrc.2010.01.011
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发表时间：
2010-02-05
影响因子：
3.1
通讯作者：
Zhao, Hong
中科院分区：
文献类型：
--
作者：
Liu, Lin;Chen, Baoan;Zhao, Hong
许多研究表明，组蛋白脱乙酰酶（HDAC）抑制剂可诱导多种肿瘤细胞发生凋亡，并且此类抑制剂已用于针对不同人类癌症的不同临床试验。在本研究中，我们设计并合成了一种新型HDAC抑制剂Chidamide。我们发现西达本胺能够增加组蛋白 H3 的乙酰化水平并抑制 PI3K/Akt 和 MAPK/Ras 信号通路，从而将结肠癌细胞阻滞在细胞周期的 G1 期并促进细胞凋亡。结果，结肠癌细胞的增殖在体外受到抑制。我们的数据支持西达本胺作为抗癌药物治疗结肠癌的潜在应用。未来的研究需要证明其体内功效。 (C) 2010 Elsevier Inc. 保留所有权利。
Many studies have demonstrated that histone deacetylase (HDAC) inhibitors induce various tumor cells to undergo apoptosis, and such inhibitors have been used in different clinical trials against different human cancers. In this study, we designed and synthesized a novel HDAC inhibitor, Chidamide. We showed that Chidamide was able to increase the acetylation levels of histone H3 and to inhibit the PI3K/Akt and MAPK/Ras signaling pathways, which resulted in arresting colon cancer cells at the G1 phase of the cell cycle and promoting apoptosis. As a result, the proliferation of colon cancer cells was suppressed in vitro. Our data support the potential application of Chidamide as an anticancer agent in treating colon cancer. Future Studies are needed to demonstrate its in vivo efficacy. (C) 2010 Elsevier Inc. All rights reserved.