MALARIA PATHOGENESIS
MALARIA PATHOGENESIS
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DOI：
10.1126/science.8009217
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发表时间：
1994-06-24
期刊：
影响因子：
56.9
通讯作者：
MILON, G
中科院分区：
文献类型：
--
作者：
MILLER, LH;GOOD, MF;MILON, G
疟疾是一种由疟原虫在红细胞中反复循环生长引起的疾病。各种细胞和分子策略允许寄生虫逃避人类免疫应答，进行寄生虫繁殖的许多循环。在某些情况下，疟原虫感染会导致严重的贫血或脑型疟疾;疾病的表现受到寄生虫和宿主因素的影响，例如怀孕期间疾病的恶化。本文综述了疟疾发病机制，综合了最近的现场，实验室和流行病学数据，将导致发展战略，以降低死亡率和发病率。
Malaria is a disease caused by repeated cycles of growth of the parasite Plasmodium in the erythrocyte. Various cellular and molecular strategies allow the parasite to evade the human immune response for many cycles of parasite multiplication. Under certain circumstances Plasmodium infection causes severe anemia or cerebral malaria; the expression of disease is influenced by both parasite and host factors, as exemplified by the exacerbation of disease during pregnancy. This article provides an overview of malaria pathogenesis, synthesizing the recent field, laboratory, and epidemiological data that will lead to the development of strategies to reduce mortality and morbidity.