Microcalcification and BMP-2 in breast cancer: correlation with clinicopathological features and outcomes
Microcalcification and BMP-2 in breast cancer: correlation with clinicopathological features and outcomes
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乳腺癌中的微钙化和 BMP-2：与临床病理特征和结果的相关性
DOI：
10.2147/ott.s187835
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发表时间：
2019-03
影响因子：
4
通讯作者：
Tong Zhongsheng
中科院分区：
文献类型：
--
作者：
Zhang Li;Hao Chunfang;Wu Yansheng;Zhu Yuying;Ren Yulin;Tong Zhongsheng
背景微钙化是诊断乳腺癌的重要信息。本研究的目的是确定乳腺癌的临床病理特征和预后与微钙化的关系，并检测与微钙化的可能机制相关的生物标志物。患者和方法所有529例微钙化的受试者都是从乳腺钼靶X线检查的患者中选出的。对照组没有可检测到的微钙化，并且以1：3的比例匹配。采用SPSS软件对临床病理因素、无进展生存期（PFS）和总生存期进行评价。结果两组肿瘤大小差异有统计学意义，钙化组肿瘤大于对照组，钙化组肿瘤> 5cm的患者比例为20.4%，对照组为17.2%（P=0.041）。钙化组淋巴结转移率高于对照组（35%vs27.9%，P=0.027）。导管原位癌（DCIS）和浸润性导管癌（IDC）伴微钙化者的复发率高于对照组（P=0.035和0.044）。BMP-2在乳腺癌组织中的表达较高，尤其是在有微钙化的乳腺癌组织中。在DCIS和IDC中，BMP-2（+）组的复发率均高于BMP-2（-）组（P=0.044和0.049）。微钙化和BMP-2阳性表达是影响乳腺癌患者PFS的独立因素。结论通过本研究的分析发现，微钙化患者的预后相对较差。BMP-2在伴有微钙化的乳腺癌中高表达，预后差。
Background Microcalcification is a very important diagnostic information in breast cancer. The purpose of this study was to determine the relationship of clinicopathological features and prognosis of breast cancer with microcalcification and to detect biomarkers related to the possible mechanisms of microcalcifications. Patients and methods All 529 subjects with microcalcifications were selected from patients who had been examined using breast mammography. The control group did not have detectable microcalcifications, and was matched in a ratio of 1:3. The clinicopathological factors, progression-free survival (PFS), and overall survival were evaluated by SPSS. Results There was a significant difference in tumor size between the two groups, with larger tumors in the calcification group than the control group, and the proportion of patients in the calcification group with tumors of >5 cm was 20.4% vs 17.2% in the control group (P=0.041). The proportion of patients with lymph node metastasis in the calcification group was higher than that of the control group (35% vs 27.9%, P=0.027). The recurrence rate in ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) patients with microcalcification was higher than that in the control group (P=0.035 and 0.044). BMP-2 expression was higher in breast cancer tissues, especially in breast cancer tissues with microcalcifications. The recurrence rate in the BMP-2(+) group was higher than that in the BMP-2(−) group both in DCIS and IDC (P=0.044 and 0.049). Microcalcifications and the positive expression of BMP-2 were independent factors affecting the PFS of the breast cancer patients. Conclusion Through the analysis of this study, it was found that the prognosis of the patients with microcalcification was relatively poor. BMP-2 was highly expressed in the breast cancer with microcalcification and was associated with poor prognosis.
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乳腺癌细胞通过 BMP2/RUNX2 信号通路诱导的上皮间质转化获得仿骨特征
影响因子：
--
作者：
Tan CC;Li GX;Tan LD;Du X;Li XQ;He R;Wang QS;Feng YM
通讯作者：
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DOI：
10.1891/9780826121646.0002
发表时间：
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期刊：
Cancer Rehabilitation
影响因子：
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影响因子：
3.7
作者：
Wang Y;Wu B;Chamberlain AA;Lui W;Koirala P;Susztak K;Klein D;Taylor V;Zhou B
通讯作者：
Zhou B
影响因子：
11.2
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影响因子：
5.2
作者：
Vincenzo Castronovo;A. Bellahcène
通讯作者：
Vincenzo Castronovo;A. Bellahcène