Avidity of IgG for Streptococcus pneumoniae type 6B and 23F polysaccharides in infants primed with pneumococcal conjugates and boosted with polysaccharide or conjugate vaccines
Avidity of IgG for Streptococcus pneumoniae type 6B and 23F polysaccharides in infants primed with pneumococcal conjugates and boosted with polysaccharide or conjugate vaccines
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DOI：
10.1086/515298
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发表时间：
1998-06-01
影响因子：
6.4
通讯作者：
Käyhty, H
中科院分区：
文献类型：
--
作者：
Anttila, M;Eskola, J;Käyhty, H
采用环境影响因子法（EIA）和嗜热剂硫氰酸盐测定了接种肺炎球菌疫苗儿童血清中IgG对6B型和23F型肺炎链球菌多糖（PSs）的相对亲和力。婴儿在2,4和6月龄时接种肺炎球菌PS-白喉环形结合疫苗，并在14月龄时接种同源结合疫苗或肺炎球菌PS疫苗。两种疫苗增强后，6B和23F PSs抗体浓度显著升高。结合疫苗后抗6b和抗23f抗体的活跃度显著增加，而非PS疫苗。在另一组接种肺炎球菌PS-脑膜炎球菌蛋白结合物并增强的婴儿中，死亡率也有所增加，但在接种肺炎球菌PS-破伤风环形结合物后接种PS疫苗的婴儿中，死亡率没有增加。而在后一组中，抗- 6b在增强前的活跃性较高。
Relative avidity of IgG to Streptococcus pneumoniae type 6B and 23F polysaccharides (PSs) was measured in sera of children immunized with pneumococcal vaccines, using an EIA and the chaotropic agent thiocyanate. Infants were immunized at 2, 4, and 6 months of age with pneumococcal PS-diphtheria toroid conjugate vaccine, and boosted at 14 months with the homologous conjugate or a pneumococcal PS vaccine. The concentrations of antibodies to 6B and 23F PSs increased significantly after the booster with both vaccines. A significant increase in the avidity of anti-6B and anti-23F antibodies was seen after the booster with conjugate but not with PS vaccine. A vidity also increased in another group of infants primed and boosted with pneumococcal PS-meningococcal protein conjugate but not in a group boosted with PS vaccine after priming with pneumococcal PS-tetanus toroid conjugate. In the latter group, however, the avidity of anti-6B was high before boosting.