Chronic widespread pain is associated with slower cognitive processing speed in middle-aged and older European men
Chronic widespread pain is associated with slower cognitive processing speed in middle-aged and older European men
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DOI：
10.1016/j.pain.2010.04.024
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发表时间：
2010-10-01
期刊：
影响因子：
7.4
通讯作者：
McBeth, J.
中科院分区：
文献类型：
--
作者：
Lee, D. M.;Pendleton, N.;McBeth, J.
临床研究表明纤维肌痛综合征（FMS）与认知功能障碍有关，但其机制尚不清楚。本分析的目的是确定在社区环境中慢性广泛性疼痛（CWP）（FMS的主要特征）与认知受损之间是否存在类似的关联。男性（n = 3369，40-79岁）被招募参加欧洲男性老龄化研究（EMAS）的人口登记在8个中心。受试者完成疼痛问卷和疼痛模型，使用美国流变学学会标准定义CWP的存在。测量的认知功能包括：视觉空间结构能力和视觉记忆（Rey-Osterrieth复杂图形[ROCF]）;视觉识别（Camden地形识别记忆测试[CTRM]）;和心理加工速度（数字符号替代测试[DSST]）。我们将分析限制在那些报告疼痛符合CWP标准的受试者和那些没有疼痛的受试者。在这1539名男性[平均（SD）年龄60（11）岁]中，266名患有CWP。所有认知测试评分均随年龄增长而呈横断面下降（P < 0.05）。在年龄校正的线性回归中，与无疼痛的受试者相比，患有CWP的男性具有较低的DSST评分（β =-2.4，P < 0.001）。在调整生活方式和健康因素后，疼痛状态和DSST评分之间的相关性减弱，但仍显着（β =-1.02，P = 0.04）。CWP与ROCF-拷贝、ROCF-回忆或CTRM评分之间无相关性。CWP与居住在社区的欧洲男性的心理处理速度较慢有关。需要进行前瞻性研究来证实这一观察结果，并探讨可能的机制。(C)2010年国际疼痛研究协会。Elsevier B. V.出版，保留所有权利。
Evidence from clinic-based studies suggests that the fibromyalgia syndrome (FMS) is associated with impairment in cognitive function though the mechanism is unclear. The aim of this analysis was to determine whether there is a similar association between chronic widespread pain (CWP), a cardinal feature of FMS, and impaired cognition in a community setting. Men (n = 3369, 40-79 years) were recruited from population registers in eight centres for participation in the European Male Ageing Study (EMAS). Subjects completed a pain questionnaire and pain manikin, with the presence of CWP defined using the American College of Rheumatology criteria. The cognitive functions measured were: visuospatial-constructional ability and visual memory (Rey-Osterrieth Complex Figure [ROCF]); visual recognition (Camden Topographical Recognition Memory test [CTRM]); and psychomotor processing speed (Digit-Symbol Substitution test [DSST]). We restricted our analysis to those subjects reporting pain that satisfied the criteria for CWP and those who were pain free. Of these 1539 men [mean (SD) age 60 (11) years], 266 had CWP. All cognitive test scores declined cross-sectionally with age (P < 0.05). In age-adjusted linear regressions men with CWP had a lower DSST score (beta = -2.4, P < 0.001) compared to pain free subjects. After adjustment for lifestyle and health factors the association between pain status and the DSST score was attenuated but remained significant (beta = -1.02, P = 0.04). There was no association between CWP and the ROCF-copy, ROCF-recall or CTRM scores. CWP is associated with slower psychomotor processing speed among community-dwelling European men. Prospective studies are required to confirm this observation and explore possible mechanisms for the association. (C) 2010 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.