Epidural morphine for postherpetic neuralgia
Epidural morphine for postherpetic neuralgia
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硬膜外吗啡治疗带状疱疹后神经痛
DOI：
10.1111/j.1365-2044.1996.tb07846.x
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发表时间：
1996
期刊：
影响因子：
10.7
通讯作者：
D. Bowsher
中科院分区：
文献类型：
--
作者：
J. Watt;J. R. Wiles;D. Bowsher
11 名已确诊带状疱疹后神经痛且对抗抑郁治疗无反应的患者参加了这项单盲、安慰剂对照研究，以评估硬膜外吗啡控制带状疱疹后神经痛疼痛的有效性。两名患者服用 0.5 毫克吗啡后疼痛减轻超过 50%。一名患者的疼痛缓解持续时间为 36 小时，另一名患者的疼痛缓解持续时间为 72 小时。然而，重复给药对一名患者无效，并导致另一名患者出现无法忍受的副作用。其他六名接受吗啡治疗的患者出现了与奥倍体相关的副作用，但疼痛却没有缓解。三名患者没有接受吗啡治疗，因为他们从安慰剂中获得了显着、持久的疼痛缓解。其中两人保留该福利超过 6 个月。当给带状疱疹后神经痛患者使用硬膜外吗啡时，它比缓解疼痛更容易产生副作用。
Eleven patients with established postherpetic neuralgia, unresponsive to antidepressant therapy, entered this single‐blind, placebo‐controlled study to assess the effectiveness of epidural morphine in the control of the pain of postherpetic neuralgia. Two patients obtained a reduction in pain of greater than 50% following morphine 0.5 mg. The duration of this pain relief was 36 h in one patient and 72 h in the other. Repeated doses, however, were ineffective in one patient and resulted in intolerable side effects in the other. The other six patients who received morphine developed oploid‐related side effects without pain relief. Three patients did not receive morphine as they gained significant, long‐lasting pain relief from placebo. Two retained that benefit for more than 6 months. Epidural morphine is more likely to produce side effects than pain relief when administered to patients with postherpetic neuralgia.