CONFORMATIONAL PREFERENCES OF AMINO-ACIDS IN GLOBULAR PROTEINS
CONFORMATIONAL PREFERENCES OF AMINO-ACIDS IN GLOBULAR PROTEINS
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DOI：
10.1021/bi00613a026
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发表时间：
1978-01-01
期刊：
影响因子：
2.9
通讯作者：
LEVITT, M
中科院分区：
文献类型：
--
作者：
LEVITT, M
在以前的一篇论文中，自动生成了50多种不同球状蛋白质的二级结构区域的客观汇编。本文分析了这些二级结构的归属，给出了α中20种天然氨基酸的出现频率。螺旋线，测试版。片状和反转二级结构。这些氨基酸中有19个对只有一种二级结构有微弱的但统计上显着的偏好。这些偏好与特定氨基酸的化学结构很好地相关，给出了比以前更客观的氨基酸构象性质的分类。
In a previous paper, an objective compilation of the secondary-structure regions in more than 50 different globular proteins was produced automatically. In the present paper, these assignments of secondary structure are analyzed to give the frequency of occurrence of the 20 naturally occurring amino acids in .alpha. helix, .beta. sheet and reverse-turn secondary structure. Nineteen of these amino acids have a weak but statistically significant preference for only 1 type of secondary structure. These preferences correlate well with the chemical structure of the particular amino acids, giving a more objective classification of the conformational properties of amino acids than available before.