The Notch ligand, Delta-1, alters retinoic acid (RA)-induced neutrophilic differentiation into monocytic and reduces RA-induced apoptosis in NB4 cells
The Notch ligand, Delta-1, alters retinoic acid (RA)-induced neutrophilic differentiation into monocytic and reduces RA-induced apoptosis in NB4 cells
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DOI：
10.1016/j.leukres.2004.05.020
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发表时间：
2005-02-01
影响因子：
2.7
通讯作者：
Nara, N
中科院分区：
文献类型：
--
作者：
Murata-Ohsawa, M;Tohda, S;Nara, N
研究了Notch激活对维甲酸（RA）诱导的细胞分化和细胞凋亡的影响。NB4是一种急性早幼粒细胞白血病（APL）细胞系，RA诱导其嗜中性分化和凋亡。重组Notch配体δ -1诱导的Notch激活本身不影响生长。RA + Delta-1使部分NB4细胞呈单核细胞样，减少凋亡。在原代APL细胞中也观察到类似的现象。RA诱导NB4中caspase-8和PARP的裂解。Delta-1抑制了ra诱导的细胞分裂，这可能是Delta-1抑制ra诱导的细胞凋亡的机制之一。(C) 2004 Elsevier Ltd.版权所有。
Effects of Notch activation on retinoic acid (RA)-induced differentiation and apoptosis were investigated. NB4, an acute promyelocytic leukemia (APL) cell line, undergoes neutrophilic differentiation and apoptosis by RA. Notch activation induced by a recombinant Notch ligand, Delta-1, did not affect the growth by itself. Treatment with RA Plus Delta-1 made part of NB4 cells monocyte-like shaped and reduced the apoptosis. Similar phenomenon was also observed in primary APL cells. RA treatment induced cleavage of caspase-8 and PARP in NB4. Delta-1 suppressed the RA-induced cleavage of them, which may be a possible mechanism through which Delta-1 Suppressed the RA-induced apoptosis. (C) 2004 Elsevier Ltd. All rights reserved.