REGULATION OF MICROTUBULE DYNAMICS BY CDC2 PROTEIN-KINASE IN CELL-FREE-EXTRACTS OF XENOPUS EGGS
REGULATION OF MICROTUBULE DYNAMICS BY CDC2 PROTEIN-KINASE IN CELL-FREE-EXTRACTS OF XENOPUS EGGS
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DOI：
10.1038/343233a0
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发表时间：
1990-01-18
期刊：
影响因子：
64.8
通讯作者：
KARSENTI, E
中科院分区：
文献类型：
--
作者：
VERDE, F;LABBE, JC;KARSENTI, E
微管参与间期囊泡的运输和有丝分裂期间染色体的运输。因此，它们在细胞中的排列和方向至关重要，而特定的模式被认为是由微管固有的动态不稳定性的调节产生的。研究表明，微管阵列的中期转变受cdc2激酶的控制，cdc2激酶精确调节微管的动力学和稳态长度。
Microtubules are involved in the transport of vesicles in interphase and of the chromosomes during mitosis. Their arrangement and orientation in the cell are therefore of prime importance and specific patterns are believed to be generated by modulations of the intrinsic dynamic instability of microtubules. Here it is shown that the interphase–metaphase transition of microtubule arrays is under the control of the cdc2 kinase that precisely regulates the dynamics and steady-state length of microtubules.